ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Determinants of action potential propagation in cerebellar Purkinje cell axons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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Who cites it
97 citing papers in PubMed.
- Dynamics of excitability in axonal trees.Biophysical journal · 2026Article
- Biophysical properties of the membrane influence spike initiation dynamics and neuronal excitability: a focus on Kv1 channels in myelinated axons.Proceedings. Biological sciences · 2025Review
- Functional properties of corticothalamic circuits targeting paraventricular thalamic neurons.Neuron · 2024Article
- Complex spikes perturb movements and reveal the sensorimotor map of Purkinje cells.Current biology : CB · 2023Article
- Development, circuitry, and function of the zebrafish cerebellum.Cellular and molecular life sciences : CMLS · 2023Review
- Diverse role of NMDA receptors for dendritic integration of neural dynamics.PLoS computational biology · 2023Article
- P-sort: an open-source software for cerebellar neurophysiology.Journal of neurophysiology · 2021Article
- Population calcium responses of Purkinje cells in the oculomotor cerebellum driven by nonvisual input.Journal of neurophysiology · 2021Article
- Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function.Nature communications · 2021Article
- Voltage-Gated Potassium Channels Ensure Action Potential Shape Fidelity in Distal Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Population coding in the cerebellum: a machine learning perspective.Journal of neurophysiology · 2020Review
- Integration of Swimming-Related Synaptic Excitation and Inhibition by olig2The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Climbing Fibers Provide Graded Error Signals in Cerebellar Learning.Frontiers in systems neuroscience · 2019Article
- Axonal Computations.Frontiers in cellular neuroscience · 2019Review
- Modulation of Ion Channels in the Axon: Mechanisms and Function.Frontiers in cellular neuroscience · 2019Review
- Cerebellar learning using perturbations.eLife · 2018Article
- Synaptic entrainment of ectopic action potential generation in hippocampal pyramidal neurons.The Journal of physiology · 2018Article
37 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
Axons have traditionally been viewed as highly faithful transmitters of action potentials. Recently, however, experimental evidence has accumulated to support the idea that under some circumstances axonal propagation may fail. Cerebellar Purkinje neurons fire highfrequency simple spikes, as well as bursts of spikes in response to climbing fiber activation (the "complex spike"). Here we have visualized the axon of individual Purkinje cells to directly investigate the relationship between somatic spikes and axonal spikes using simultaneous somatic whole-cell and cell-attached axonal patch-clamp recordings at 200-800 microm from the soma. We demonstrate that sodium action potentials propagate at frequencies up to approximately 260 Hz, higher than simple spike rates normally observed in vivo. Complex spikes, however, did not propagate reliably, with usually only the first and last spikes in the complex spike waveform being propagated. On average, only 1.7 +/- 0.2 spikes in the complex spike were propagated during resting firing, with propagation limited to interspike intervals above approximately 4 msec. Hyperpolarization improved propagation efficacy without affecting total axonal spike number, whereas strong depolarization could abolish propagation of the complex spike. These findings indicate that the complex spike waveform is not faithfully transmitted to downstream synapses and that propagation of the climbing fiber response may be modulated by background activity.
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