ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Regulation of gephyrin cluster size and inhibitory synaptic currents on Renshaw cells by motor axon excitatory inputs.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- The Calcium-Binding Protein S100A10 (p11) Is Required for Normal Motor Performance by Regulating Vesicle Dynamics at Excitatory Synapses.Acta physiologica (Oxford, England) · 2026Article
- Synaptic imbalance and increased inhibition impair motor function in SMA.Science advances · 2025Article
- Dissection of signaling pathways regulating TrkB-dependent gephyrin clustering.Frontiers in molecular neuroscience · 2024Article
- Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats.International journal of molecular sciences · 2022Article
- Nociception in the Glycine Receptor Deficient Mutant Mouse Spastic.Frontiers in molecular neuroscience · 2022Article
- Review
- Article
- Regulation of GABAergic synapse development by postsynaptic membrane proteins.Brain research bulletin · 2017Review
- Role of primary afferents in the developmental regulation of motor axon synapse numbers on Renshaw cells.The Journal of comparative neurology · 2016Article
- Principles of interneuron development learned from Renshaw cells and the motoneuron recurrent inhibitory circuit.Annals of the New York Academy of Sciences · 2013Review
- Beyond muscular effects: depression of spinal recurrent inhibition after botulinum neurotoxin A.The Journal of physiology · 2013Article
- Mixed inhibitory synaptic balance correlates with glutamatergic synaptic phenotype in cerebellar unipolar brush cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Renshaw cells and Ia inhibitory interneurons are generated at different times from p1 progenitors and differentiate shortly after exiting the cell cycle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Synaptic changes underlying the strengthening of GABA/glycinergic connections in the developing lateral superior olive.Neuroscience · 2010Article
- Activity-dependent codevelopment of the corticospinal system and target interneurons in the cervical spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Excitatory and inhibitory intermediate zone interneurons in pathways from feline group I and II afferents: differences in axonal projections and input.The Journal of physiology · 2009Article
- The time course of transmitter at glycinergic synapses onto motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- The continuing case for the Renshaw cell.The Journal of physiology · 2007Review
- Primary afferent synapses on developing and adult Renshaw cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Cytoskeleton regulation of glycine receptor number at synapses and diffusion in the plasma membrane.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renshaw cells receive a high density of inhibitory synapses characterized by large postsynaptic gephyrin clusters and mixed glycinergic/GABAergic inhibitory currents with large peak amplitudes and long decays. These properties appear adapted to increase inhibitory efficacy over Renshaw cells and mature postnatally by mechanisms that are unknown. We tested the hypothesis that heterosynaptic influences from excitatory motor axon inputs modulate the development of inhibitory synapses on Renshaw cells. Thus, tetanus (TeNT) and botulinum neurotoxin A (BoNT-A) were injected intramuscularly at postnatal day 5 (P5) to, respectively, elevate or reduce motor axon firing activity for approximately 2 weeks. After TeNT injections, the average gephyrin cluster areas on Renshaw cells increased by 18.4% at P15 and 28.4% at P20 and decreased after BoNT-A injections by 17.7% at P15 and 19.9% at P20. The average size differences resulted from changes in the proportions of small and large gephyrin clusters. Whole-cell recordings in P9-P15 Renshaw cells after P5 TeNT injections showed increases in the peak amplitude of glycinergic miniature postsynaptic currents (mPSCs) and the fast component of mixed (glycinergic/GABAergic) mPSCs compared with controls (60.9% and 78.9%, respectively). GABAergic mPSCs increased in peak amplitude to a smaller extent (45.8%). However, because of the comparatively longer decays of synaptic GABAergic currents, total current transfer changes after TeNT were similar for synaptic glycine and GABA(A) receptors (56 vs 48.9% increases, respectively). We concluded that motor axon excitatory synaptic activity modulates the development of inhibitory synapse properties on Renshaw cells, influencing recruitment of postsynaptic gephyrin and glycine receptors and, to lesser extent, GABA(A) receptors.
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