ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
High-threshold K+ current increases gain by offsetting a frequency-dependent increase in low-threshold K+ current.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 26 citations in OpenAlex.
- Distinct neuron phenotypes may serve object feature sensing in the electrosensory lobe of Gymnotus omarorum.The Journal of experimental biology · 2021Article
- Kv3-like potassium channels are required for sustained high-frequency firing in basal ganglia output neurons.Journal of neurophysiology · 2011Article
- Mechanisms of sustained high firing rates in two classes of vestibular nucleus neurons: differential contributions of resurgent Na, Kv3, and BK currents.Journal of neurophysiology · 2010Article
- Population coding by electrosensory neurons.Journal of neurophysiology · 2008Article
- Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels.The Journal of physiology · 2007Article
- Muscarinic receptors control frequency tuning through the downregulation of an A-type potassium current.Journal of neurophysiology · 2007Article
- Distribution and function of potassium channels in the electrosensory lateral line lobe of weakly electric apteronotid fish.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2006Review
- A C-terminal domain directs Kv3.3 channels to dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Ionic and neuromodulatory regulation of burst discharge controls frequency tuning.Journal of physiology, ParisReview
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
High-frequency firing neurons are found in numerous central systems, including the auditory brainstem, thalamus, hippocampus, and neocortex. The kinetics of high-threshold K+ currents (IK(HT)) from the Kv3 subfamily has led to the proposal that these channels offset cumulative Na+ current inactivation and stabilize tonic high-frequency firing. However, all high-frequency firing neurons, examined to date, also express low-threshold K+ currents (IK(LT)) that have slower kinetics and play an important role in setting the subthreshold and filtering properties of the neuron. IK(LT) has also been shown to dampen excitability and is therefore likely to oppose high-frequency firing. In this study, we examined the role of IK(HT) in pyramidal cells of the electrosensory lobe of weakly electric fish, which are characterized by high-frequency firing, a very wide frequency range, and high levels of IK(HT). In particular, we examined the mechanisms that allow IK(HT) to set the gain of the F-I relationship by interacting with another low-threshold K+ current. We found that IK(HT) increases the gain of the F-I relationship and influences spike waveform almost exclusively in the high-frequency firing range. The frequency dependence arises from IK(HT) influencing both the IK(LT) and Na+ currents. IK(HT) thus plays a significant role in stabilizing high-frequency firing by preventing a steady-state accumulation of IK(LT) that is as important as preventing Na+ current inactivation.
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