ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Modifier of cell adhesion regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Molecular Basis of Na, K-ATPase Regulation of Diseases: Hormone and FXYD2 Interactions.International journal of molecular sciences · 2024Review
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- The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders.Protein & cell · 2022Review
- Both Intracranial and Intravenous Administration of Functionalized Carbon Nanotubes Protect Dopaminergic Neuronal Death from 6-Hydroxydopamine.International journal of nanomedicine · 2020Article
- The relationship between DNA methylation andOncotarget · 2017Article
- Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons.Scientific reports · 2017Article
- Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal Models.Molecular neurobiology · 2016Article
- Cooperation of distinct Rac-dependent pathways to stabilise E-cadherin adhesion.Cellular signalling · 2015Article
- Article
- Regulating Rac in the nervous system: molecular function and disease implication of Rac GEFs and GAPs.BioMed research international · 2015Review
- The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases.Frontiers in cellular neuroscience · 2014Review
- Dock protein family in brain development and neurological disease.Communicative & integrative biology · 2013Review
- Dock3 interaction with a glutamate-receptor NR2D subunit protects neurons from excitotoxicity.Molecular brain · 2013Article
- Notch activation stimulates migration of breast cancer cells and promotes tumor growth.Breast cancer research : BCR · 2013Article
- Activation of ezrin/radixin/moesin mediates attractive growth cone guidance through regulation of growth cone actin and adhesion receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The atypical Guanine-nucleotide exchange factor, dock7, negatively regulates schwann cell differentiation and myelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The DOCK protein sponge binds to ELMO and functions in Drosophila embryonic CNS development.PloS one · 2011Article
- DISC1 regulates cell-cell adhesion, cell-matrix adhesion and neurite outgrowth.Molecular psychiatry · 2010Article
- Loss of modifier of cell adhesion reveals a pathway leading to axonal degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- A novel functional screen in human cells identifies MOCA as a negative regulator of Wnt signaling.Molecular biology of the cell · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Modifier of cell adhesion (MOCA) is a member of the dedicator of cytokinesis 180 family of proteins and is highly expressed in CNS neurons. MOCA is associated with Alzheimer's disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Here, we report that MOCA modulates cell-cell adhesion and morphology. MOCA increases the accumulation of adherens junction proteins, including N-cadherin and beta-catenin, whereas reducing endogenous MOCA expression lowers cell-cell aggregation and N-cadherin expression. MOCA colocalizes with N-cadherin and actin in areas of cell-cell and cell substratum contact and is expressed in neuronal processes. MOCA accumulates during neuronal differentiation, and its expression enhances NGF-induced neurite outgrowth and morphological complexity. We conclude that MOCA regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.