ArticleProceedings of the National Academy of Sciences of the United States of America2005
Elevated evolutionary rates in the laboratory strain of Saccharomyces cerevisiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 88 citations in OpenAlex.
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- Gains and Losses of Transcription Factor Binding Sites in Saccharomyces cerevisiae and Saccharomyces paradoxus.Genome biology and evolution · 2015Article
- Continuous evolution of laboratory strains of bacteria and yeast.Journal of biosciences · 2014Article
- Heterosis is prevalent among domesticated but not wild strains of Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2014Article
- Divergence in a master variator generates distinct phenotypes and transcriptional responses.Genes & development · 2014Article
- Domestication and the mitochondrial genome: comparing patterns and rates of molecular evolution in domesticated mammals and birds and their wild relatives.Genome biology and evolution · 2014Article
- Contrasted evolutionary constraints on secreted and non-secreted proteomes of selected Actinobacteria.BMC genomics · 2013Article
- Nonlinear fitness consequences of variation in expression level of a eukaryotic gene.Molecular biology and evolution · 2013Article
- The new modern era of yeast genomics: community sequencing and the resulting annotation of multiple Saccharomyces cerevisiae strains at the Saccharomyces Genome Database.Database : the journal of biological databases and curation · 2013Article
- Natural genetic variation in yeast longevity.Genome research · 2012Article
- Genetic architecture of highly complex chemical resistance traits across four yeast strains.PLoS genetics · 2012Article
- Pitfalls of establishing DNA barcoding systems in protists: the cryptophyceae as a test case.PloS one · 2012Article
- Role of pleiotropy in the evolution of a cryptic developmental variation in Caenorhabditis elegans.PLoS biology · 2012Article
- The making of a new pathogen: insights from comparative population genomics of the domesticated wheat pathogen Mycosphaerella graminicola and its wild sister species.Genome research · 2011Article
- Article
- Idealization in evolutionary developmental investigation: a tension between phenotypic plasticity and normal stages.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
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6 authors at 2 institutions in 2 countries.
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Abstract
By using the maximum likelihood method, we made a genome-wide comparison of the evolutionary rates in the lineages leading to the laboratory strain (S288c) and a wild strain (YJM789) of Saccharomyces cerevisiae and found that genes in the laboratory strain tend to evolve faster than in the wild strain. The pattern of elevated evolution suggests that relaxation of selection intensity is the dominant underlying reason, which is consistent with recurrent bottlenecks in the S. cerevisiae laboratory strain population. Supporting this conclusion are the following observations: (i) the increases in nonsynonymous evolutionary rate occur for genes in all functional categories; (ii) most of the synonymous evolutionary rate increases in S288c occur in genes with strong codon usage bias; (iii) genes under stronger negative selection have a larger increase in nonsynonymous evolutionary rate; and (iv) more genes with adaptive evolution were detected in the laboratory strain, but they do not account for the majority of the increased evolution. The present discoveries suggest that experimental and possible industrial manipulations of the laboratory strain of yeast could have had a strong effect on the genetic makeup of this model organism. Furthermore, they imply an evolution of laboratory model organisms away from their wild counterparts, questioning the relevancy of the models especially when extensive laboratory cultivation has occurred. In addition, these results shed light on the evolution of livestock and crop species that have been under human domestication for years.
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