ArticleGut2005
Serum antibodies to carbonic anhydrase IV in patients with autoimmune pancreatitis.
Article in Gut, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary Sjögren syndrome: results of an epidemiologic systematic review/meta-analysis and a consensus guideline from the Brazilian society of rheumatology (hepatic, gastrointestinal and pancreatic).Advances in rheumatology (London, England) · 2022Guideline
- IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein.Vaccines · 2023Review
- The Clinical Utility of Soluble Serum Biomarkers in Autoimmune Pancreatitis: A Systematic Review.Biomedicines · 2022Review
- Neutralizing anti-IL-1 receptor antagonist autoantibodies induce inflammatory and fibrotic mediators in IgG4-related disease.The Journal of allergy and clinical immunology · 2022Article
- Histological features of autoimmune pancreatitis and IgG4-related sclerosing cholangitis with a correlation with imaging findings.Journal of medical ultrasonics (2001) · 2021Review
- The Cellular and Molecular Bases of Allergy, Inflammation and Tissue Fibrosis in Patients with IgG4-related Disease.International journal of molecular sciences · 2020Review
- Carbonic anhydrases as disease markers.Expert opinion on therapeutic patents · 2019Review
- [Pathogenesis of immunoglobulin G4-related hepatobiliary disease].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018Article
- The Immunologic Paradoxes of IgG4-Related Disease.Clinical reviews in allergy & immunology · 2018Review
- IgG4-related disease: a complex under-diagnosed clinical entity.Rheumatology international · 2018Review
- Current perspectives on autoimmune pancreatitis and IgG4-related disease.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Review
- Immunoglobulin G4-related kidney disease: Pathogenesis, diagnosis, and treatment.Chronic diseases and translational medicine · 2017Review
- Distinct pathophysiological cytokine profiles for discrimination between autoimmune pancreatitis, chronic pancreatitis, and pancreatic ductal adenocarcinoma.Journal of translational medicine · 2017Article
- Testing for Anti-PBP Antibody Is Not Useful in Diagnosing Autoimmune Pancreatitis.The American journal of gastroenterology · 2016Article
- IgG4-related hepatobiliary disease: an overview.Nature reviews. Gastroenterology & hepatology · 2016Review
- An overview of the diagnosis and management of immunoglobulin G4-related disease.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016Review
- Autoimmune pancreatitis.Gland surgery · 2016Review
- Potential role of Th17 cells in the pathogenesis of type 2 autoimmune pancreatitis.Virchows Archiv : an international journal of pathology · 2015Article
- Immunology of IgG4-related disease.Clinical and experimental immunology · 2015Review
- Recent advances in the concept and pathogenesis of IgG4-related disease in the hepato-bilio-pancreatic system.Gut and liver · 2014Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsSerum antibodies to carbonic anhydrase (CA) II have been reported in patients with autoimmune pancreatitis (AIP) and Sjogren's syndrome (SjS). However, their significance in the pathogenesis of these diseases is controversial. The aim of this study was to identify serum antibodies to CA isozymes, which are expressed in ductal cells of the pancreas.
methodsRecombinant proteins of human CAs IV, IX, and XII were obtained using a bacterial expression system, and five CA IV peptides with theoretically high antigenicity were synthesised. Western blotting and enzyme linked immunosorbent assay (ELISA) were used to detect serum antibodies to the CA isozymes.
resultsThe first screening analysis by western blot showed serum antibodies to CA IV among three CA isozymes in patients with idiopathic chronic pancreatitis, including AIP patients. Further analysis by ELISA showed a significantly increased prevalence of serum antibodies to the truncated CA IV protein and the CA IV synthetic peptide (LGS LTT PTC DEK VVW TVF REP I) in patients with definite AIP (4/15 and 6/20, respectively; p<0.01), probable AIP (6/14 and 3/14; p<0.02), and SjS (9/20 and 8/40; p<0.001) compared with normal controls (0/26). There was no significant difference in the antibody prevalence rates between normal controls and patients with alcoholic chronic pancreatitis (2/15 in each) or pancreatic cancer (2/14 and 1/14, respectively). The presence of serum antibodies to the CA IV peptide showed significant correlations with serum gamma-globulin and IgG levels in AIP patients.
conclusionsThese findings suggest that CA IV may be a target antigen that is commonly expressed in epithelial cells of specific tissues involved in AIP and its related diseases.
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