ArticleGut2005
Epithelioid granulomas, pattern recognition receptors, and phenotypes of Crohn's disease.
Article in Gut, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Associations between NOD2/CARD15 genotype and phenotype in Crohn's disease--Are we there yet?World journal of gastroenterology · 2006Pooled it
- Xenobiotic Toxicants and Particulate Matter: Effects, Mechanisms, Impacts on Human Health, and Mitigation Strategies.Journal of xenobiotics · 2025Review
- Upper gastrointestinal tract involvement of pediatric inflammatory bowel disease: A pathological review.World journal of gastroenterology · 2019Review
- Identification of the distinguishing features of Crohn's disease and ischemic colitis using computed tomographic enterography.Gastroenterology report · 2017Article
- Inflammatory bowel disease in Chinese children: A retrospective analysis of 49 cases.Experimental and therapeutic medicine · 2016Article
- Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease.Gastroenterology · 2014Article
- Article
- Toll-like receptors and human disease: lessons from single nucleotide polymorphisms.Current genomics · 2012Article
- Microbiota separation and C-reactive protein elevation in treatment-naïve pediatric granulomatous Crohn disease.Journal of pediatric gastroenterology and nutrition · 2012Article
- Role of genetics in the diagnosis and prognosis of Crohn's disease.World journal of gastroenterology · 2012Review
- Role of genetics in the diagnosis and prognosis of Crohn's disease.World journal of gastroenterology · 2011Review
- New insights into gastrointestinal and hepatic granulomatous disorders.Nature reviews. Gastroenterology & hepatology · 2011Review
- Frequency of epithelioid granulomas in colonoscopic biopsy specimens from paediatric and adult patients with Crohn's colitis.Journal of clinical pathology · 2007Review
- Granuloma-positive Crohn's disease.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2007Article
- The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Blau syndrome and related genetic disorders causing childhood arthritis.Current rheumatology reports · 2005Review
- Review
- Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCrohn's disease is a chronic inflammatory disorder of the gut. It is assumed that a defective interaction between the bacterial flora of the gut and the innate immune system plays a key role in the pathogenesis of the disease. This may lead to specific histological lesions. The epithelioid granuloma is particularly interesting in this regard as it is also observed in several bacterial infections of the gut. AIMS AND
methodsWe hypothesised that genetic or environmental factors with a known influence on inflammation or immunity would lead to an increased prevalence of granulomas. Therefore, surgical specimens from 161 patients were evaluated for the presence of granulomas. Patients were genotyped for the three single nucleotide polymorphisms in caspase recruitment domain 15 (CARD15)/NOD2 associated with CD and for Asp299Gly in Toll-like receptor 4 (TLR4).
resultsThe overall prevalence of granulomas was 68.9%. We did not find a significant correlation between granulomas and TLR4 or CARD15 variants. The frequency of granulomas increased with more distal disease (63% small bowel, 72% right colon, 88% left colon, 90% rectum; p=0.01). Granulomas were more frequent in younger patients (odds ratio 0.95 (95% confidence interval 0.92-0.98) p=0.007).
conclusionIn this study of 161 well documented CD patients, we found no significant association between CARD15 and TLR4 variants and granulomas. This finding seems to refute our initial hypothesis. However, it may be that additional factors are needed for granuloma development. Granulomas may develop only when specific bacterial components are present. Therefore, future research on granuloma pathogenesis should be orientated towards detection and identification of bacterial components in these lesions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.