ArticleGut2005
Frequency and significance of granulomas in a cohort of incident cases of Crohn's disease.
Article in Gut, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- Systematic Review: Evaluating the Prognostic Value of Granulomas in Crohn's Disease.Digestive diseases and sciences · 2026Pooled it
- Associations between NOD2/CARD15 genotype and phenotype in Crohn's disease--Are we there yet?World journal of gastroenterology · 2006Pooled it
- Crohn's lymphoid aggregates with endothelial clusters colocalise with submucosal fibrosis in fibrostenosing Crohn's disease.The Journal of pathology · 2026Article
- Monocyte-macrophages modulate intestinal homeostasis in inflammatory bowel disease.Biomarker research · 2024Review
- Detection Rates of Non-Cavitary Epithelioid Cell Granuloma by Gastrointestinal Biopsy in Patients with Treatment-Naïve Crohn's Disease.Inflammatory intestinal diseases · 2023Article
- Exome Sequencing Implicates DGKZ , ESRRA , and GXYLT1 for Modulating Granuloma Formation in Crohn Disease.Journal of pediatric gastroenterology and nutrition · 2023Article
- Macrophages in intestinal homeostasis and inflammatory bowel disease.Nature reviews. Gastroenterology & hepatology · 2023Review
- PF-431396 hydrate inhibition of kinase phosphorylation during adherent-invasiveMicrobiology (Reading, England) · 2023Article
- Single cell RNA-sequencing profiling to improve the translation between human IBD andFrontiers in immunology · 2023Review
- Diagnosis and Monitoring of Ulcerative Colitis.Clinics in colon and rectal surgery · 2022Review
- Algorithmic Approach to Inflammatory Disorders of Ileum.Iranian journal of pathology · 2022Review
- Composite outcomes in observational studies of Crohn's disease: a systematic review and meta-analysis.Therapeutic advances in gastroenterology · 2022Article
- Histopathological Features in Colonic Biopsies at Diagnosis Predict Long-term Disease Course in Patients with Crohn's Disease.Journal of Crohn's & colitis · 2021Article
- Episodic, severe abdominal pain due to isolated jejunal Crohn's disease.Clinical journal of gastroenterology · 2021Article
- Outcomes of Pediatric Fistulising Perianal Crohn's Disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- Crohn's disease of esophagus, stomach and duodenum.World journal of gastrointestinal pharmacology and therapeutics · 2019Review
- Differentiation of Crohn's disease and ulcerative colitis using intestinal wall thickness of the colon: A Diagnostic accuracy study of endoscopic ultrasonography.Medical journal of the Islamic Republic of Iran · 2019Article
- Mesenteric Lymphatic Vessel Density Is Associated with Disease Behavior and Postoperative Recurrence in Crohn's Disease.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2018Article
- Granulomas in the gastrointestinal tract: deciphering the Pandora's box.Virchows Archiv : an international journal of pathology · 2018Review
- Identification of the distinguishing features of Crohn's disease and ischemic colitis using computed tomographic enterography.Gastroenterology report · 2017Article
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsEpithelioid granulomas is one of the best histological criterion for distinguishing Crohn's disease (CD) from other inflammatory bowel diseases. Few data are available on the time of occurrence of epithelioid granulomas, and the value of epithelioid granulomas in predicting outcome has been determined only in cohorts of prevalent CD cases. Our objective was to evaluate epithelioid granuloma occurrence in incident CD cases and to examine the associations between epithelioid granulomas and outcome. PATIENTS AND
methodsWe reviewed the histological reports of endoscopic and surgical specimens in a cohort of 188 consecutive incident CD cases seen in 1994 and 1995, and recorded the occurrence of epithelioid granulomas, isolated giant cells, and microgranulomas. Kaplan-Meier curves were plotted for time from CD diagnosis to immunosuppressive treatment or surgery, and associations between epithelioid granulomas and outcome were evaluated in a multivariate analysis. Follow up was at least five years.
resultsGranulomas were found in 69 (37%) patients, including 46 (25%) at presentation. Median time from CD diagnosis to epithelioid granuloma detection was 0.16 (0-63) months overall, and 9.59 (0.1-63) months in 23 patients who became epithelioid granuloma positive during follow up. Isolated giant cells were found in 6% of patients and microgranulomas in 12%. Epithelioid granuloma detection increased with the number of endoscopic sampling procedures; sampling site had no influence. By multivariate analysis, epithelioid granulomas were associated with surgical resection but not immunosuppressive therapy.
conclusionsEpithelioid granulomas may separate CD into two pathological subsets and may indicate aggressive disease.
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