ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2004
Myosin I and adaptation of mechanical transduction by the inner ear.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Mechanosensitive interactions between Jag1 and Myo1c control Jag1 trafficking in endothelial cells.iScience · 2025Article
- Membrane-bound myosin IC drives the chiral rotation of the gliding actin filament around its longitudinal axis.Scientific reports · 2023Article
- The motor protein Myo1c regulates transforming growth factor-β-signaling and fibrosis in podocytes.Kidney international · 2019Article
- Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs.Development (Cambridge, England) · 2016Article
- miR-137 plays tumor suppressor roles in gastric cancer cell lines by targeting KLF12 and MYO1C.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Class I myosins have overlapping and specialized functions in left-right asymmetric development in Drosophila.Genetics · 2015Article
- Myo1c is an unconventional myosin required for zebrafish glomerular development.Kidney international · 2013Article
- Membrane-bound myo1c powers asymmetric motility of actin filaments.Current biology : CB · 2012Article
- Myosin IC generates power over a range of loads via a new tension-sensing mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A hearing loss-associated myo1c mutation (R156W) decreases the myosin duty ratio and force sensitivity.Biochemistry · 2011Article
- Molecular biology of hearing.GMS current topics in otorhinolaryngology, head and neck surgery · 2011Article
- Localization of myosin 1b to actin protrusions requires phosphoinositide binding.The Journal of biological chemistry · 2010Article
- Control of myosin-I force sensing by alternative splicing.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Identifying components of the hair-cell interactome involved in cochlear amplification.BMC genomics · 2009Article
- Calcium regulation of calmodulin binding to and dissociation from the myo1c regulatory domain.Biochemistry · 2007Article
- Fifty years on: where have we reached?Journal of muscle research and cell motility · 2006Article
- Introduction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2004Article
- A model of stereocilia adaptation based on single molecule mechanical studies of myosin I.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 2 institutions in 1 country.
Funding
Abstract
Twenty years ago, the description of hair-cell stereocilia as actin-rich structures led to speculation that myosin molecules participated in mechanical transduction in the inner ear. In 1987, Howard and Hudspeth proposed specifically that a myosin I might mediate adaptation of the transduction current carried by hair cells, the sensory cells of the ear. We exploited the myosin literature to design tests of this hypothesis and to show that the responsible isoform is myosin 1c. The identification of this myosin as the adaptation motor would have been impossible without thorough experimentation on other myosins, particularly muscle myosins. The sliding-filament hypothesis for muscle contraction has thus led to a detailed understanding of the behaviour of hair cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.