ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2004
Recent X-ray diffraction studies of muscle contraction and their implications.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- ATP directly modulates thick filament structure and function in porcine myocardium.Biophysical journal · 2025Article
- Thick-Filament-Based Regulation and the Determinants of Force Generation.Biomedicines · 2025Article
- Differences in thick filament activation in fast rodent skeletal muscle and slow porcine cardiac muscle.The Journal of physiology · 2024Article
- The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation.The Journal of general physiology · 2023Article
- Thick filament activation is different in fast- and slow-twitch skeletal muscle.The Journal of physiology · 2022Article
- Small Angle X-ray Diffraction as a Tool for Structural Characterization of Muscle Disease.International journal of molecular sciences · 2022Review
- The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium.Circulation research · 2021Article
- Thick-Filament Extensibility in Intact Skeletal Muscle.Biophysical journal · 2018Article
- Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle.International journal of molecular sciences · 2018Article
- Synchrotron Radiation X-ray Diffraction Techniques Applied to Insect Flight Muscle.International journal of molecular sciences · 2018Review
- Lessons from a tarantula: new insights into muscle thick filament and myosin interacting-heads motif structure and function.Biophysical reviews · 2017Review
- Kinetic coupling of phosphate release, force generation and rate-limiting steps in the cross-bridge cycle.Journal of muscle research and cell motility · 2017Review
- Poorly understood aspects of striated muscle contraction.BioMed research international · 2015Review
- Thick-filament strain and interfilament spacing in passive muscle: effect of titin-based passive tension.Biophysical journal · 2011Article
- Geometrical conditions indispensable for muscle contraction.International journal of molecular sciences · 2011Article
- Fifty years on: where have we reached?Journal of muscle research and cell motility · 2006Article
- Muscle contraction: actin filaments enter the fray.Biophysical journal · 2005Article
- Introduction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2004Article
- The path to visualization of walking myosin V by high-speed atomic force microscopy.Biophysical reviewsArticle
Corrections and comments
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1 author.
Funding
Abstract
Recent studies on the interference fringes in the myosin meridional reflections provide a new source of structural information on cross-bridge movement during mechanical transients and steady shortening. Many observations can be interpreted satisfactorily by the tilting lever-arm model, with some assumptions, including the presence of fixed repeating structures contributing to the M3 and higher-order meridional reflections. In isometric contraction, the lever arms are oriented near the start of the working stroke, with a dispersion of ca+/-20-25 degrees . Upon a rapid release of 10-12 nm, they move to the end of the stroke, with a well-known T2 delay of 1-2 ms. This delay must represent additional processes, which have to occur even in tension-generating heads, or activation of attached heads, which initially do not develop force. Surprisingly, in muscles shortening at moderate loads (0.5-0.6 P0), the mean position of the heads moves only 2-3 nm closer to the M-line than in the isometric case, reminiscent of the Piazzesi-Lombardi model.
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Registered trials
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