ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2004
The motor mechanism of myosin V: insights for muscle contraction.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 67 citations in OpenAlex.
- CaBiomolecules · 2025Review
- Myosin-5 varies its step length to carry cargo straight along the irregular F-actin track.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- From amoeboid myosin to unique targeted medicines for a genetic cardiac disease.Frontiers in physiology · 2024Review
- Roles and regulation of myosin V interaction with cargo.Advances in biological regulation · 2021Review
- The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches.Annual review of biochemistry · 2020Review
- Converter domain mutations in myosin alter structural kinetics and motor function.The Journal of biological chemistry · 2019Article
- Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light.Biophysical reviews · 2018Review
- Structure of actomyosin rigour complex at 5.2 Å resolution and insights into the ATPase cycle mechanism.Nature communications · 2017Article
- Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity.Nature communications · 2015Article
- How actin initiates the motor activity of Myosin.Developmental cell · 2015Article
- Functions and mechanics of dynein motor proteins.Nature reviews. Molecular cell biology · 2013Review
- Multiple causes of fatigue during shortening contractions in rat slow twitch skeletal muscle.PloS one · 2013Article
- Global fit analysis of myosin-5b motility reveals thermodynamics of Mg2+-sensitive acto-myosin-ADP states.PloS one · 2013Article
- A subdomain interaction at the base of the lever allosterically tunes the mechanochemical mechanism of myosin 5a.PloS one · 2013Article
- Allosteric communication in Dictyostelium myosin II.Journal of muscle research and cell motility · 2012Article
- Switching of myosin-V motion between the lever-arm swing and brownian search-and-catch.Nature communications · 2012Article
- Three-dimensional reconstructions of Arp2/3 complex with bound nucleation promoting factors.The EMBO journal · 2012Article
- A conformational transition in the myosin VI converter contributes to the variable step size.Biophysical journal · 2011Article
- Actin filament dynamics in the actomyosin VI complex is regulated allosterically by calcium-calmodulin light chain.Journal of molecular biology · 2011Article
- Attenuated fatigue in slow twitch skeletal muscle during isotonic exercise in rats with chronic heart failure.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is 50 years since the sliding of actin and myosin filaments was proposed as the basis of force generation and shortening in striated muscle. Although this is now generally accepted, the detailed molecular mechanism of how myosin uses adenosine triphosphate to generate force during its cyclic interaction with actin is only now being unravelled. New insights have come from the unconventional myosins, especially myosin V. Myosin V is kinetically tuned to allow movement on actin filaments as a single molecule, which has led to new kinetic, mechanical and structural data that have filled in missing pieces of the actomyosin-chemo-mechanical transduction puzzle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.