ArticleMolecular and cellular biochemistry2004
Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats.
Article in Molecular and cellular biochemistry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 73 citations in OpenAlex.
- In vivo and in vitro investigations of schisandrin B against angiotensin II induced ferroptosis and atrial fibrosis by regulation of the SIRT1 pathway.Scientific reports · 2025Article
- Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88-Dependent Inflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases.Medicinal research reviews · 2021Review
- A Comprehensive Review on Schisandrin B and Its Biological Properties.Oxidative medicine and cellular longevity · 2020Review
- Schisandrin B attenuates pressure overload-induced cardiac remodeling in mice by inhibiting the MAPK signaling pathway.Experimental and therapeutic medicine · 2019Article
- Schisandrin B Ameliorates Myocardial Ischemia/Reperfusion Injury Through Attenuation of Endoplasmic Reticulum Stress-Induced Apoptosis.Inflammation · 2017Article
- Short-term treadmill exercise in a cold environment does not induce adrenal Hsp72 and Hsp25 expression.The journal of physiological sciences : JPS · 2017Article
- Article
- A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration.PloS one · 2016Article
- Article
- Stress protein expression in early phase spinal cord ischemia/reperfusion injury.Neural regeneration research · 2013Article
- Effects and mechanisms of chinese herbal medicine in ameliorating myocardial ischemia-reperfusion injury.Evidence-based complementary and alternative medicine : eCAM · 2013Review
- Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction.PloS one · 2013Article
- Cytochrome P-450-catalyzed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in H9c2 cardiomyocytes.Indian journal of pharmacology · 2012Article
- Adaptogens stimulate neuropeptide y and hsp72 expression and release in neuroglia cells.Frontiers in neuroscience · 2012Article
- The immuno-regulatory effects of Schisandra chinensis and its constituents on human monocytic leukemia cells.Molecules (Basel, Switzerland) · 2011Article
- Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells.Molecular and cellular biochemistry · 2011Article
- Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress-Protective Activity.Pharmaceuticals (Basel, Switzerland) · 2010Review
- (-)Schisandrin B is more potent than its enantiomer in enhancing cellular glutathione and heat shock protein production as well as protecting against oxidant injury in H9c2 cardiomyocytes.Molecular and cellular biochemistry · 2006Article
- The systemic theory of living systems and relevance to CAM: the theory (Part III).Evidence-based complementary and alternative medicine : eCAM · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schisandrin B (Sch B) is a hepato- and cardioprotective ingredient isolated from the fruit of Schisandra chinensis, a traditional Chinese herb clinically used to treat viral and chemical hepatitis. In order to investigate whether the induction of heat shock protein (Hsp)25 and Hsp70 expression plays a role in the cardioprotection afforded by Sch B pre-treatment against ischemia-reperfusion (I-R) injury, the time-course of myocardial Hsp25 and Hsp70 expression was examined in Sch B-pre-treated rats. Sch B pre-treatment (1.2 mmol/kg) produced time-dependent increases in Hsp25 and Hsp70 expression in rat hearts, with the maximum enhancement observable at 48 and 72 h post-dosing, respectively. Buthionine sulfoximine/phorone treatment, while abolishing the beneficial effect of Sch B on mitochondrial glutathione redox status, did not completely abrogate the cardioprotection against I-R injury. Heat shock treatment could increase myocardial Hsp25 and Hsp70 expression and protect against I-R injury under the present experimental conditions. The results indicate that the induction of Hsp25 and Hsp70 expression contributes at least partly to the cardioprotection afforded by Sch B pre-treatment against I-R injury.
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