ArticleMolecular and cellular biochemistry2004
Retinoic acid administration and vitamin A status modulate retinoid X receptor alpha and retinoic acid receptor alpha levels in mouse brown adipose tissue.
Article in Molecular and cellular biochemistry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Gene Expression Shifts in Emperor Penguin Adaptation to the Extreme Antarctic Environment.Molecular ecology · 2025Article
- The brown fat-specific overexpression of RBP4 improves thermoregulation and systemic metabolism by activating the canonical adrenergic signaling pathway.Experimental & molecular medicine · 2025Article
- Adipose retinol saturase is regulated by β-adrenergic signaling and its deletion impairs lipolysis in adipocytes and acute cold tolerance in mice.Molecular metabolism · 2024Article
- Association of dietary antioxidant index with body mass index in adolescents.Obesity science & practice · 2023Article
- Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis.Molecular metabolism · 2020Article
- Vitamin A Supplementation during Suckling and Postweaning Periods Attenuates the Adverse Metabolic Effects of Maternal High-Fat Diet Consumption in Sprague-Dawley Rats.Current developments in nutrition · 2020Review
- Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders.Pharmacology & therapeutics · 2019Review
- The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism.Journal of clinical medicine · 2014Review
- Mitochondriogenesis and apoptosis: possible cause of vitamin A-mediated adipose loss in WNIN/Ob-obese rats.Nutrition & metabolism · 2014Article
- Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes.BMC cell biology · 2013Article
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Authors and funding
4 authors.
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Abstract
BACKGROUND/
aimsRetinoic acid (RA), the carboxylic acid form of vitamin A, through the activation of cognate receptors, stimulates the transcription of the gene encoding uncoupling protein 1 (UCP1), which is critical to brown adipose tissue (BAT) thermogenesis. RA was previously shown to down-regulate the steady state levels of retinoic acid receptor alpha (RARalpha) and retinoid X receptor alpha (RXRalpha) in primary brown adipocytes differentiated in culture. Our aim was to study the impact of RA-treatment and vitamin A status on the expression levels of these receptors in vivo.
methodsThree-week-old mice were fed standard chow or a vitamin A deficient diet for 10 weeks, after which animals on both diets were treated with all-trans RA (ATRA, 100 mg x Kg(-1) day(-1)) or vehicle during 4 days. Levels of UCP1, RARalpha and RXRalpha in BAT were determined by immunoblotting.
resultsATRA-treatment resulted in a reduction of the specific RARalpha and especially RXRalpha content in BAT that paralleled the induction of UCP1 appearance in the tissue. RARalpha and RXRalpha levels per gram of BAT were reduced in mice chronically fed the vitamin A-deficient diet.
conclusionRA modulates the expression of cognate receptors in BAT, suggesting auto regulation of the retinoid effect on the thermogenic system.
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