ReviewJournal of neurology2004
Development and malformations of the human pyramidal tract.
Review in Journal of neurology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 133 citations in OpenAlex.
- A Discussion of a Case of Paradoxical Ipsilateral Hemiparesis in a Patient Diagnosed with Pterional Meningioma.Journal of clinical medicine · 2025Article
- Retrospective analysis of 11 patients with ipsilateral hemiplegia caused by acute cerebral infarction.Frontiers in neurology · 2025Article
- A rare case of ispilateral hemiparesis in a patient with uncrossed pyramidal tract shown by tractography.Radiology case reports · 2024Article
- Brain Pathways in LIS1-Associated Lissencephaly Revealed by Diffusion MRI Tractography.Brain sciences · 2023Article
- Atypical fetal brain development in fetuses with non-syndromic isolated musculoskeletal birth defects (niMSBDs).Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- Structural networking of the developing brain: from maturation to neurosurgical implications.Frontiers in neuroanatomy · 2023Review
- Structure of the Motor Descending Pathways Correlates with the Temporal Kinematics of Hand Movements.Biology · 2022Article
- Review
- Clinical and neuroimaging findings in patients with lissencephaly/subcortical band heterotopia spectrum: a magnetic resonance conventional and diffusion tensor study.Neuroradiology · 2022Article
- Hypoplasia of dopaminergic neurons by hypoxia-induced neurotoxicity is associated with disrupted swimming development of larval zebrafish.Frontiers in cellular neuroscience · 2022Article
- Between Limb Muscle Co-activation Patterns in the Paretic Arm During Non-paretic Arm Tasks in Hemiparetic Cerebral Palsy.Frontiers in neuroscience · 2021Article
- Article
- Focal loss of the paranodal domain protein Neurofascin155 in the internal capsule impairs cortically induced muscle activity in vivo.Molecular brain · 2020Article
- Frequency distribution in intraoperative stimulation-evoked EMG responses during selective dorsal rhizotomy in children with cerebral palsy-part 2: gender differences and left-biased asymmetry.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Individual movement features during prism adaptation correlate with after-effects and interlimb transfer.Psychological research · 2020Article
- Uncrossed corticospinal tracts in a patient with ichthyosis and hemiparesis: a case report.BMC neurology · 2020Article
- The spectrum of brainstem malformations associated to mutations of the tubulin genes family: MRI and DTI analysis.European radiology · 2019Article
- Building an Asymmetrical Brain: The Molecular Perspective.Frontiers in psychology · 2019Review
- Hypoxia and connectivity in the developing vertebrate nervous system.Disease models & mechanisms · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The corticospinal tract develops over a rather long period of time, during which malformations involving this main central motor pathway may occur. In rodents, the spinal outgrowth of the corticospinal tract occurs entirely postnatally, but in primates largely prenatally. In mice, an increasing number of genes have been found to play a role during the development of the pyramidal tract. In experimentally studied mammals, initially a much larger part of the cerebral cortex sends axons to the spinal cord, and the site of termination of corticospinal fibers in the spinal grey matter is much more extensive than in adult animals. Selective elimination of the transient corticospinal projections yields the mature projections functionally appropriate for the pyramidal tract. Direct corticomotoneuronal projections arise as the latest components of the corticospinal system. The subsequent myelination of the pyramidal tract is a slow process, taking place over a considerable period of time. Available data suggest that in man the pyramidal tract develops in a similar way. Several variations in the funicular trajectory of the human pyramidal tract have been described in otherwise normally developed cases, the most obvious being those with uncrossed pyramidal tracts. A survey of the neuropathological and clinical literature, illustrated with autopsy cases, reveals that the pyramidal tract may be involved in a large number of developmental disorders. Most of these malformations form part of a broad spectrum, ranging from disorders of patterning, neurogenesis and neuronal migration of the cerebral cortex to hypoxic-ischemic injury of the white matter. In some cases, pyramidal tract malformations may be due to abnormal axon guidance mechanisms. The molecular nature of such disorders is only beginning to be revealed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.