ArticleDevelopment genes and evolution2005
Self-organization vs Watchmaker: stochastic gene expression and cell differentiation.
Article in Development genes and evolution, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Non-linearity, complexity, and quantization concepts in biology.Frontiers in human neuroscience · 2025Article
- Perspective: Controlling Epidermal Terminal Differentiation with Transcriptional Bursting and RNA Bodies.Journal of developmental biology · 2020Review
- Evolution of Self-Organized Task Specialization in Robot Swarms.PLoS computational biology · 2015Article
- Modularity and evolutionary constraints in a baculovirus gene regulatory network.BMC systems biology · 2013Article
- Article
- The self-organizing fractal theory as a universal discovery method: the phenomenon of life.Theoretical biology & medical modelling · 2011Article
- Scale-free flow of life: on the biology, economics, and physics of the cell.Theoretical biology & medical modelling · 2009Article
- Emergent genome-wide control in wildtype and genetically mutated lipopolysaccarides-stimulated macrophages.PloS one · 2009Article
- Generation of synthetic transcriptome data with defined statistical properties for the development and testing of new analysis methods.Genomics, proteomics & bioinformatics · 2007Article
- Article
- High-sensitivity transcriptome data structure and implications for analysis and biologic interpretation.Genomics, proteomics & bioinformatics · 2006Article
- Chromatin code, local non-equilibrium dynamics, and the emergence of transcription regulatory programs.The European physical journal. E, Soft matter · 2006Article
- Fundamental awareness: A framework for integrating science, philosophy and metaphysics.Communicative & integrative biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell differentiation and organism development are traditionally described in deterministic terms of program and design, echoing a conventional clockwork perception of the cell on another scale. However, the current experimental reality of stochastic gene expression and cell plasticity is poorly consistent with the ideas of design, purpose and determinism, suggesting that the habit of classico-mechanistic interpretation of life phenomena may handicap our ability to adequately comprehend and model biological systems. An alternative conceptualization of cell differentiation and development is proposed where the developing organism is viewed as a dynamic self-organizing system of adaptive interacting agents. This alternative interpretation appears to be more consistent with the probabilistic nature of gene expression and the phenomena of cell plasticity, and is coterminous with the novel emerging image of the cell as a self-organizing molecular system. I suggest that stochasticity, as a principle of differentiation and adaptation, and self-organization, as a concept of emergence, have the potential to provide an interpretational framework that unites phenomena across different scales of biological organization, from molecules to societies.
Indexed as
Identifiers
15645318What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.