ArticleHuman genetics2005
A genomewide scan of male sexual orientation.
Article in Human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Probing the genomic landscape of human sexuality: a critical systematic review of the literature.Frontiers in genetics · 2023Pooled it
- Genome-Wide Linkage Study Meta-Analysis of Male Sexual Orientation.Archives of sexual behavior · 2021Pooled it
- Mining the Gaps: Rethinking Divergence Between Biological and Self-Report Measures in the Study of Sexual Diversity.American journal of human biology : the official journal of the Human Biology Council · 2026Review
- Gender/Sex Preferences May Moderate the Relationship between Cohabitation and Sibling Incest.Archives of sexual behavior · 2025Article
- Biodevelopmental Correlates of Sexual Orientation in Men: Evidence from a Polish Sample.Archives of sexual behavior · 2025Article
- Biological, genetic, neurological and environmental influences on homosexuality-a narrative review.Frontiers in behavioral neuroscience · 2025Review
- The methodological and ethical concerns of genetic studies of same-sex sexual behavior.American journal of human genetics · 2024Review
- Genetic variants underlying human bisexual behavior are reproductively advantageous.Science advances · 2024Article
- Hormonal, Genetic, Immunological: An Array of Mechanisms but How Do They Interact, If at All?Archives of sexual behavior · 2023Article
- Variations in gender identity and sexual orientation of university students.Sexual medicine · 2023Article
- Science, Scripture, and Sexuality: The US United Methodist Church at Crossroads.Journal of religion and health · 2023Article
- Accurate machine learning prediction of sexual orientation based on brain morphology and intrinsic functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Genome-Wide Linkage and Association Study of Childhood Gender Nonconformity in Males.Archives of sexual behavior · 2021Article
- Discovery of new genetic loci for male sexual orientation in Han population.Cell discovery · 2021Article
- Executive function and its relation to anatomical connectome in homosexual and heterosexual men.Quantitative imaging in medicine and surgery · 2020Article
- Sexual partner preference in animals and humans.Neuroscience and biobehavioral reviews · 2020Review
- Factors Associated with PrEP Support and Disclosure Among YMSM and Transgender Individuals Assigned Male at Birth in Chicago.AIDS and behavior · 2019Article
- Evidence for distinct biodevelopmental influences on male sexual orientation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Prosociality and a Sociosexual Hypothesis for the Evolution of Same-Sex Attraction in Humans.Frontiers in psychology · 2019Article
- Neurobiology of gender identity and sexual orientation.Journal of neuroendocrinology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
This is the first report of a full genome scan of sexual orientation in men. A sample of 456 individuals from 146 families with two or more gay brothers was genotyped with 403 microsatellite markers at 10-cM intervals. Given that previously reported evidence of maternal loading of transmission of sexual orientation could indicate epigenetic factors acting on autosomal genes, maximum likelihood estimations (mlod) scores were calculated separated for maternal, paternal, and combined transmission. The highest mlod score was 3.45 at a position near D7S798 in 7q36 with approximately equivalent maternal and paternal contributions. The second highest mlod score of 1.96 was located near D8S505 in 8p12, again with equal maternal and paternal contributions. A maternal origin effect was found near marker D10S217 in 10q26, with a mlod score of 1.81 for maternal meioses and no paternal contribution. We did not find linkage to Xq28 in the full sample, but given the previously reported evidence of linkage in this region, we conducted supplemental analyses to clarify these findings. First, we re-analyzed our previously reported data and found a mlod of 6.47. We then re-analyzed our current data, after limiting the sample to those families previously reported, and found a mlod of 1.99. These Xq28 findings are discussed in detail. The results of this first genome screen for normal variation in the behavioral trait of sexual orientation in males should encourage efforts to replicate these findings in new samples with denser linkage maps in the suggested regions.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.