ArticleBritish journal of pharmacology2005
Contrasting anesthetic sensitivities of T-type Ca2+ channels of reticular thalamic neurons and recombinant Ca(v)3.3 channels.
Article in British journal of pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- The effect of early and intensive statin therapy on ventricular premature beat or nonsustained ventricular tachycardia in patients with acute coronary syndrome.Clinical cardiology · 2011Trial
- Time to Wake Up! The Ongoing Search for General Anesthetic Reversal Agents.Anesthesiology · 2024Article
- Sex-specific hypnotic effects of the neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid.British journal of anaesthesia · 2023Article
- General Anesthesia and the Young Brain: The Importance of Novel Strategies with Alternate Mechanisms of Action.International journal of molecular sciences · 2022Review
- Synthetic neuroactive steroids as new sedatives and anaesthetics: Back to the future.Journal of neuroendocrinology · 2022Review
- Selective blockade of rat brain T-type calcium channels provides insights on neurophysiological basis of arousal dependent resting state functional magnetic resonance imaging signals.Frontiers in neuroscience · 2022Article
- Global genetic deletion of CaScientific reports · 2020Article
- The Effects of General Anesthetics on Synaptic Transmission.Current neuropharmacology · 2020Review
- Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum.British journal of anaesthesia · 2019Article
- Influence of propofol on isolated neonatal rat carotid body glomus cell response to hypoxia and hypercapnia.Respiratory physiology & neurobiology · 2019Article
- A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain.British journal of anaesthesia · 2018Article
- The role of T-type calcium channels in the subiculum: to burst or not to burst?The Journal of physiology · 2017Article
- Redox regulation of neuronal voltage-gated calcium channels.Antioxidants & redox signaling · 2014Review
- Article
- Alcohol and the sleeping brain.Handbook of clinical neurology · 2014Review
- Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.Alcoholism, clinical and experimental research · 2013Article
- Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane.Neuropharmacology · 2012Article
- [Postoperative cognitive dysfunction. Possible neuronal mechanisms and practical consequences for clinical routine].Der Anaesthesist · 2012Review
- The sleep relay--the role of the thalamus in central and decentral sleep regulation.Pflugers Archiv : European journal of physiology · 2012Review
- T-type voltage-gated calcium channels as targets for the development of novel pain therapies.British journal of pharmacology · 2011Review
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5 authors.
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Abstract
Reticular thalamocortical neurons express a slowly inactivating T-type Ca(2+) current that is quite similar to that recorded from recombinant Ca(v)3.3b (alpha1Ib) channels. These neurons also express abundant Ca(v)3.3 mRNA, suggesting that it underlies the native current. Here, we test this hypothesis by comparing the anesthetic sensitivities of recombinant Ca(v)3.3b channels stably expressed in HEK 293 cells to native T channels in reticular thalamic neurons (nRT) from brain slices of young rats. Barbiturates completely blocked both Ca(v)3.3 and nRT currents, with pentobarbital being about twice more potent in blocking Ca(v)3.3 currents. Isoflurane had about the same potency in blocking Ca(v)3.3 and nRT currents, but enflurane, etomidate, propofol, and ethanol exhibited 2-4 fold higher potency in blocking nRT vs Ca(v)3.3 currents. Nitrous oxide (N(2)O; laughing gas) blocked completely nRT currents with IC(50) of 20%, but did not significantly affect Ca(v)3.3 currents at four-fold higher concentrations. In addition, we observed that in lower concentration, N(2)O reversibly increased nRT but not Ca(v)3.3 currents. In conclusion, contrasting anesthetic sensitivities of Ca(v)3.3 and nRT T-type Ca(2+) channels strongly suggest that different molecular structures of Ca(2+) channels give rise to slowly inactivating T-type Ca(2+) currents. Furthermore, effects of volatile anesthetics and ethanol on slowly inactivating T-type Ca(2+) channel variants may contribute to the clinical effects of these agents.
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