ArticleNucleic acids research2005
Rapid, solid-phase based automated analysis of chromatin structure and transcription factor occupancy in living eukaryotic cells.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- A highly sensitive in vivo footprinting technique for condition-dependent identification of cis elements.Nucleic acids research · 2014Article
- A library-based method to rapidly analyse chromatin accessibility at multiple genomic regions.Nucleic acids research · 2009Article
- PAP-LMPCR for improved, allele-specific footprinting and automated chromatin fine structure analysis.Nucleic acids research · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
Transcription factors, chromatin components and chromatin modification activities are involved in many diseases including cancer. However, the means by which alterations in these factors influence the epigenotype of specific cell types is poorly understood. One problem that limits progress is that regulatory regions of eukaryotic genes sometimes extend over large regions of DNA. To improve chromatin structure-function analysis over such large regions, we have developed an automated, relatively simple procedure that uses magnetic beads and a capillary sequencer for ligation-mediated-PCR (LM-PCR). We show that the procedure can be used for the rapid examination of chromatin fine-structure, nucleosome positioning as well as changes in transcription factor binding-site occupancy during cellular differentiation.
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Registered trials
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