ArticleMalaria journal2005
Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum.
Article in Malaria journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 170 citations in OpenAlex.
- Mosquito feeding assays to determine the infectiousness of naturally infected Plasmodium falciparum gametocyte carriers.PloS one · 2012Trial
- Submicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western Kenya.PloS one · 2009Trial
- Genetic basis of resistance in hosts facing alternative infection strategies by a virulent bacterial pathogen.G3 (Bethesda, Md.) · 2025Article
- Warming alters life-history traits and competition in a phage community.Applied and environmental microbiology · 2024Article
- Intervention reducing malaria parasite load in vector mosquitoes: No impact on Plasmodium falciparum extrinsic incubation period and the survival of Anopheles gambiae.PLoS pathogens · 2023Article
- Identification of microbial taxa present in Ctenocephalides felis (cat flea) reveals widespread co-infection and associations with vector phylogeny.Parasites & vectors · 2022Article
- Susceptibility of primary, secondary and suspected vectors to Plasmodium vivax and Plasmodium falciparum infection in Ethiopia.Parasites & vectors · 2022Article
- Between virus correlations in the outcome of infection across host species: Evidence of virus by host species interactions.Evolution letters · 2021Article
- Higher mortality of the less suitable brown trout host compared to the principal Atlantic salmon host when infested with freshwater pearl mussel (Margaritifera margaritifera) glochidia.Parasitology research · 2021Article
- Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections.Nature communications · 2021Article
- The Stable Matching Problem in TBEV Enzootic Circulation: How Important Is the Perfect Tick-Virus Match?Microorganisms · 2021Article
- Exome-wide association study reveals largely distinct gene sets underlying specific resistance to dengue virus types 1 and 3 in Aedes aegypti.PLoS genetics · 2020Article
- Among-Strain Variation in Resistance ofFrontiers in microbiology · 2020Article
- High genetic diversity but no geographical structure of Aedes albopictus populations in Réunion Island.Parasites & vectors · 2019Article
- An interaction between host and microbe genotypes determines colonization success of a key bumble bee gut microbiota member.Evolution; international journal of organic evolution · 2019Article
- Host (Salmo trutta) age influences resistance to infestation by freshwater pearl mussel (Margaritifera margaritifera) glochidia.Parasitology research · 2019Article
- Specificity of resistance and geographic patterns of virulence in a vertebrate host-parasite system.BMC evolutionary biology · 2019Article
- An Evolutionary Perspective on Vector-Borne Diseases.Frontiers in genetics · 2019Review
- A transcriptomic snapshot of early molecular communication between Pasteuria penetrans and Meloidogyne incognita.BMC genomics · 2018Article
- Article
23 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost studies on the resistance of mosquitoes to their malaria parasites focus on the response of a mosquito line or colony against a single parasite genotype. In natural situations, however, it may be expected that mosquito-malaria relationships are based, as are many other host-parasite systems, on host genotype by parasite genotype interactions. In such systems, certain hosts are resistant to one subset of the parasite's genotypes, while other hosts are resistant to a different subset.
methodsTo test for genotype by genotype interactions between malaria parasites and their anopheline vectors, different genetic backgrounds (families consisting of the F1 offspring of individual females) of the major African vector Anopheles gambiae were challenged with several isolates of the human malaria parasite Plasmodium falciparum (obtained from naturally infected children in Kenya).
resultsAveraged across all parasites, the proportion of infected mosquitoes and the number of oocysts found in their midguts were similar in all mosquito families. Both indices of resistance, however, differed considerably among isolates of the parasite. In particular, no mosquito family was most resistant to all parasites, and no parasite isolate was most infectious to all mosquitoes.
conclusionsThese results suggest that the level of mosquito resistance depends on the interaction between its own and the parasite's genotype. This finding thus emphasizes the need to take into account the range of genetic diversity exhibited by mosquito and malaria field populations in ideas and studies concerning the control of malaria.
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