ArticleNature neuroscience2005
Endocytosis-dependent desensitization and protein synthesis-dependent resensitization in retinal growth cone adaptation.
Article in Nature neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 155 citations in OpenAlex.
- Stochastic growth and ligand-receptor interaction-mediated stabilization generate stereotyped dendritic arbors.Nature neuroscience · 2026Article
- A human DCC variant causing mirror movement disorder reveals that the WAVE regulatory complex mediates axon guidance by netrin-1-DCC.Science signaling · 2024Article
- The Axonal Actin Filament Cytoskeleton: Structure, Function, and Relevance to Injury and Degeneration.Molecular neurobiology · 2024Review
- Semaphorin-3A regulates liver sinusoidal endothelial cell porosity and promotes hepatic steatosis.Nature cardiovascular research · 2024Article
- Failure to Upregulate the RNA Binding Protein ZBP After Injury Leads to Impaired Regeneration in a Rodent Model of Diabetic Peripheral Neuropathy.Frontiers in molecular neuroscience · 2021Article
- Inositol 1,4,5-Trisphosphate Receptor Type 3 Regulates Neuronal Growth Cone Sensitivity to Guidance Signals.iScience · 2020Article
- Cocktail Napkin Presentations: Design of an Activity to Enhance Undergraduate Communication and Critical Evaluation of Neuroscience Primary Literature.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2020Article
- Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons.eLife · 2019Article
- A crucial role for Arf6 in the response of commissural axons to Slit.Development (Cambridge, England) · 2019Article
- Micropatterned nanolayers immobilized with nerve growth factor for neurite formation of PC12 cells.International journal of nanomedicine · 2019Article
- Stepwise wiring of theeLife · 2018Article
- Axonal mRNA transport and translation at a glance.Journal of cell science · 2018Review
- Expanding Axonal Transcriptome Brings New Functions for Axonally Synthesized Proteins in Health and Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- Cue-Polarized Transport of β-actin mRNA Depends on 3'UTR and Microtubules in Live Growth Cones.Frontiers in cellular neuroscience · 2018Article
- Article
- Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons.Scientific reports · 2017Article
- Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits.Nature communications · 2017Article
- Multi-phasic bi-directional chemotactic responses of the growth cone.Scientific reports · 2016Article
- ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis.Open biology · 2016Article
- Membrane Trafficking in Neuronal Development: Ins and Outs of Neural Connectivity.International review of cell and molecular biology · 2016Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
It has been proposed that growth cones navigating through gradients adapt to baseline concentrations of guidance cues. This adaptation process is poorly understood. Using the collapse assay, we show that adaptation in Xenopus laevis retinal growth cones to the guidance cues Sema3A or netrin-1 involves two processes: a fast, ligand-specific desensitization that occurs within 2 min of exposure and is dependent on endocytosis, and a slower, ligand-specific resensitization, which occurs within 5 min and is dependent upon protein synthesis. These two phases of adaptation allow retinal axons to adjust their range of sensitivity to specific guidance cues.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.