ArticleEukaryotic cell2005
Demonstration of loss of heterozygosity by single-nucleotide polymorphism microarray analysis and alterations in strain morphology in Candida albicans strains during infection.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 83 citations in OpenAlex.
- Experimental Evolution of PathogenicMicroorganisms · 2026Review
- Probing gene function inmSphere · 2024Article
- Loss of Heterozygosity and Its Importance in Evolution.Journal of molecular evolution · 2023Review
- Host Defense Mechanisms Induce Genome Instability Leading to Rapid Evolution in an Opportunistic Fungal Pathogen.Infection and immunity · 2022Article
- Molecular typing of multi-drug resistant Candida albicans isolated from the Segamat community, Malaysia.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.FEMS microbiology reviews · 2021Review
- Drug resistance and tolerance in fungi.Nature reviews. Microbiology · 2020Review
- Molecular and genetic basis of azole antifungal resistance in the opportunistic pathogenic fungus Candida albicans.The Journal of antimicrobial chemotherapy · 2020Review
- Mechanisms of genome evolution in Candida albicans.Current opinion in microbiology · 2019Review
- Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype.PLoS genetics · 2019Article
- Flow Cytometry Analysis of Fungal Ploidy.Current protocols in microbiology · 2018Article
- Rapid Phenotypic and Genotypic Diversification After Exposure to the Oral Host Niche inGenetics · 2018Article
- Ploidy Variation in Fungi: Polyploidy, Aneuploidy, and Genome Evolution.Microbiology spectrum · 2017Review
- Comparative molecular dynamics studies of heterozygous open reading frames of DNA polymerase eta (η) in pathogenic yeast Candida albicans.Scientific reports · 2017Article
- Budding off: bringing functional genomics to Candida albicans.Briefings in functional genomics · 2016Review
- Last hope for the doomed? Thoughts on the importance of a parasexual cycle for the yeast Candida albicans.Current genetics · 2016Review
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- Molecular fingerprints to identify Candida species.BioMed research international · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Candida albicans is a diploid yeast with a predominantly clonal mode of reproduction, and no complete sexual cycle is known. As a commensal organism, it inhabits a variety of niches in humans. It becomes an opportunistic pathogen in immunocompromised patients and can cause both superficial and disseminated infections. It has been demonstrated that genome rearrangement and genetic variation in isolates of C. albicans are quite common. One possible mechanism for generating genome-level variation among individuals of this primarily clonal fungus is mutation and mitotic recombination leading to loss of heterozygosity (LOH). Taking advantage of a recently published genome-wide single-nucleotide polymorphism (SNP) map (A. Forche, P. T. Magee, B. B. Magee, and G. May, Eukaryot. Cell 3:705-714, 2004), an SNP microarray was developed for 23 SNP loci residing on chromosomes 5, 6, and 7. It was used to examine 21 strains previously shown to have undergone mitotic recombination at the GAL1 locus on chromosome 1 during infection in mice. In addition, karyotypes and morphological properties of these strains were evaluated. Our results show that during in vivo passaging, LOH events occur at observable frequencies, that such mitotic recombination events occur independently in different loci across the genome, and that changes in karyotypes and alterations of phenotypic characteristics can be observed alone, in combination, or together with LOH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.