ReviewBreast cancer research : BCR2005
Towards an integrated model for breast cancer etiology: the crucial role of the number of mammary tissue-specific stem cells.
Review in Breast cancer research : BCR, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Genetic architecture of mammographic density as a risk factor for breast cancer: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Pooled it
- Pre-natal exposures and breast tissue composition: findings from a British pre-birth cohort of young women and a systematic review.Breast cancer research : BCR · 2016Pooled it
- Intrauterine environments and breast cancer risk: meta-analysis and systematic review.Breast cancer research : BCR · 2008Pooled it
- PARP Pioneers: Using BRCA1/2 Mutation-targeted Inhibition to Revolutionize Breast Cancer Treatment.Current pharmaceutical design · 2025Review
- Review
- Association between skeletal muscle mass and mammographic breast density.Scientific reports · 2021Article
- Dietary polyunsaturated fatty acids modulate adipose secretome and is associated with changes in mammary epithelial stem cell self-renewal.The Journal of nutritional biochemistry · 2019Article
- The association between weight at birth and breast cancer risk revisited using Mendelian randomisation.European journal of epidemiology · 2019Article
- Breast cancer protection by genomic imprinting in close kin families.BMC medical genetics · 2017Review
- Adiposity, breast density, and breast cancer risk: epidemiological and biological considerations.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2017Review
- Effect of preeclampsia on umbilical cord blood stem cells in relation to breast cancer susceptibility in the offspring.Carcinogenesis · 2015Article
- Article
- Timing of pubertal stages and breast cancer risk: the Breakthrough Generations Study.Breast cancer research : BCR · 2014Article
- Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway.Cell cycle (Georgetown, Tex.) · 2013Article
- Prenatal DES exposure in relation to breast size.Cancer causes & control : CCC · 2013Article
- Implication of the Strand-Specific Imprinting and Segregation Model: IntegratingHereditary genetics : current research · 2013Article
- Role of obesity in the risk of breast cancer: lessons from anthropometry.Journal of oncology · 2013Article
- Obstetric history and mammographic density: a population-based cross-sectional study in Spain (DDM-Spain).Breast cancer research and treatment · 2012Article
- A model for breast cancer risk based on stem-cell theory.Current oncology (Toronto, Ont.) · 2012Article
- Novel measurements of mammary stem cells in human umbilical cord blood as prospective predictors of breast cancer susceptibility in later life.Annals of oncology : official journal of the European Society for Medical Oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perinatal events and conditions, notably birth weight, are associated with breast cancer risk in offspring, and correlates of mammary gland mass are predictors of breast cancer risk. These findings may be interpreted as indicating that high levels of estrogens and components of the insulin-like growth factor system during pregnancy favour the generation of mammary tissue-specific stem cells, and that the number of these cells, which is positively associated with mammary gland mass, is an important determinant of breast cancer risk. Perinatal events and conditions may also affect risk for other malignancies, but the evidence in the case of breast cancer is prominent, possibly because estrogens and the insulin-like growth factor system are both involved in breast cancer etiology and affect birth weight.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.