ArticleBreast cancer research : BCR2005
Systemic chemotherapy induces microsatellite instability in the peripheral blood mononuclear cells of breast cancer patients.
Article in Breast cancer research : BCR, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Case report: immunotherapy response in pancreatic cancer after MSI-H emerged post-chemotherapy.Frontiers in oncology · 2026Article
- Mismatch Repair System Gene Expression in FFPE Samples from Breast Cancer Patients.Medical sciences (Basel, Switzerland) · 2025Article
- Enhanced detection of microsatellite instability using pre-PCR elimination of wild-type DNA homo-polymers in tissue and liquid biopsies.Nucleic acids research · 2018Article
- Analysis of cancer marker in tissues with Hadamard transform fluorescence spectral microscopic imaging.Journal of fluorescence · 2015Article
- Chemotherapy induced microsatellite instability and loss of heterozygosity in chromosomes 2, 5, 10, and 17 in solid tumor patients.Cancer cell international · 2014Article
- Breast tumors with elevated expression of 1q candidate genes confer poor clinical outcome and sensitivity to Ras/PI3K inhibition.PloS one · 2013Article
- Article
- Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT.Science translational medicine · 2011Article
- A hybrid machine learning-based method for classifying the Cushing's Syndrome with comorbid adrenocortical lesions.BMC genomics · 2008Article
- Changes in allelic imbalances in locally advanced breast cancers after chemotherapy.British journal of cancer · 2007Article
- Heparanase expression in circulating lymphocytes of breast cancer patients depends on the presence of the primary tumor and/or systemic metastasis.Neoplasia (New York, N.Y.) · 2007Article
- Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSystemic chemotherapy is an important part of treatment for breast cancer. We conducted the present study to evaluate whether systemic chemotherapy could produce microsatellite instability (MSI) in the peripheral blood mononuclear cell fraction of breast cancer patients.
methodsWe studied 119 sequential blood samples from 30 previously untreated breast cancer patients before, during and after chemotherapy. For comparison, we also evaluated 20 women who had no relevant medical history (control group).
resultsIn 27 out of 30 patients we observed MSI in at least one sample, and six patients had loss of heterozygosity. We found a significant correlation between the number of MSI events per sample and chemotherapy with alkylating agents (P < 0.0001). We also observed an inverse correlation between the percentage of cells positive for hMSH2 and the number of MSI events per sample (P = 0.00019) and use of alkylating agents (P = 0.019).
conclusionWe conclude that systemic chemotherapy may induce MSI and loss of heterozygosity in peripheral blood mononuclear cells from breast cancer patients receiving alkylating agents, possibly mediated by a chemotherapy-induced decrease in the expression of hMSH2. These effects may be related to the generation of secondary leukaemia in some patients, and may also intensify the genetic instability of tumours and increase resistance to treatment.
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