ArticleArthritis research & therapy2005
Interleukin-18: a therapeutic target in rheumatoid arthritis?
Article in Arthritis research & therapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The intellectual base and research fronts of IL-18: A bibliometric review of the literature from WoSCC (2012-2022).Cell proliferation · 2024Review
- IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in osteoarthritis synovial fibroblasts.Aging · 2024Article
- High cumulative glucocorticoid dose is associated with increased levels of inflammation-related mediators in active rheumatoid arthritis.Frontiers in immunology · 2024Article
- Investigation of genetically regulated gene expression and response to treatment in rheumatoid arthritis highlights an association betweenAnnals of the rheumatic diseases · 2020Article
- Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation.Nutrients · 2020Article
- T Cell Migration in Rheumatoid Arthritis.Frontiers in immunology · 2015Review
- The class III histone deacetylase sirtuin 1 in immune suppression and its therapeutic potential in rheumatoid arthritis.Journal of genetics and genomics = Yi chuan xue bao · 2013Review
- Article
- Genetics of interleukin 1 receptor-like 1 in immune and inflammatory diseases.Current genomics · 2010Article
- Expression of interleukin-18, IL-18BP, and IL-18R in serum, synovial fluid, and synovial tissue in patients with rheumatoid arthritis.Clinical and experimental medicine · 2009Article
- Identification of the most active interleukin-32 isoform.Immunology · 2009Article
- Evidence that cytokines play a role in rheumatoid arthritis.The Journal of clinical investigation · 2008Review
- Form-deprivation myopia in chick induces limited changes in retinal gene expression.Investigative ophthalmology & visual science · 2007Article
- Novel insights in the regulation of CCL18 secretion by monocytes and dendritic cells via cytokines, toll-like receptors and rheumatoid synovial fluid.BMC immunology · 2006Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin 18 (IL-18), a member of the IL-1 superfamily of cytokines has been demonstrated to be an important mediator of both innate and adaptive immune responses. Several reports have implicated its role in the pathogenesis of rheumatoid arthritis (RA). Although biologic therapy is firmly established in the treatment of a number of inflammatory diseases including RA, partial and non-responder patients constitute residual unmet clinical need. The aim of this article is to briefly review the biology of, and experimental approaches to IL-18 neutralisation, together with speculation as to the relative merits of IL-18 as an alternative to existing targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.