ArticleWorld journal of gastroenterology2005
Plasma interleukin-18 reflects severity of ulcerative colitis.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Dual roles of IL-18 in colitis through regulation of the function and quantity of goblet cells.International journal of molecular medicine · 2019Pooled it
- Pyroptosis in ulcerative colitis: biomarkers and therapeutic targets.Journal of biomedical science · 2025Review
- Article
- Causal relationship between asthma and ulcerative colitis and the mediating role of interleukin-18: a bidirectional Mendelian study and mediation analysis.Frontiers in immunology · 2023Article
- Effects of indigo naturalis on colonic mucosal injuries and inflammation in rats with dextran sodium sulphate-induced ulcerative colitis.Experimental and therapeutic medicine · 2017Article
- The mRNA level of the transforming growth factor β1 gene, but not the amount of the gene product, can be considered as a potential prognostic parameter in inflammatory bowel diseases in children.International journal of colorectal disease · 2013Article
- Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation.The Journal of biological chemistry · 2008Article
- Stimulatory and costimulatory effects of IL-18 directed to different small intestinal CD43 T cell subsets.Journal of leukocyte biology · 2007Article
- T-cell activation in the intestinal mucosa.Immunological reviews · 2007Review
- Serum interleukin-1 receptor antagonist is an early indicator of colitis onset in Galphai2-deficient mice.World journal of gastroenterology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this study was to evaluate the association between ulcerative colitis activity and plasma or mucosal concentrations of interleukin (IL)-18.
methodsIl-18 concentrations were measured in plasma and mucosal samples from 15 patients with active ulcerative colitis (UC).
resultsThe mean plasma concentration of IL-18 measured in all patients (422+/-88 pg/mL) doubled the mean value in healthy controls (206+/-32 pg/mL); however, the difference was not statistically significant. Plasma IL-18 levels revealed a significant positive correlation with scored endoscopic degree of mucosal injury, disease activity index, clinical activity index and C-reactive protein concentration. The mean concentration of plasma IL-18 was significantly higher in patients with severe ulcerative colitis (535+/-115 pg/mL) than in patients with mild ulcerative colitis (195+/-41 pg/mL), and in healthy controls. Although the mucosal mean IL-18 concentration in severe ulcerative colitis (2 523+/-618 pg/mg protein) doubled values observed in mild one (1 347+/-308 pg/mg protein), there was no statistically significant difference.
conclusionPlasma IL-18 can be considered as a surrogate marker helpful in evaluation of ulcerative colitis activity.
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