ReviewOncogene2005
The Plk3-Cdc25 circuit.
Review in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer.Nature communications · 2024Article
- Variant cell cycles regulated by Notch signaling control cell size and ensure a functional blood-brain barrier.Development (Cambridge, England) · 2018Article
- The G2 checkpoint-a node-based molecular switch.FEBS open bio · 2017Article
- Acetylation and deacetylation of Cdc25A constitutes a novel mechanism for modulating Cdc25A functions with implications for cancer.Oncotarget · 2016Article
- The role of Plk3 in oncogenesis.Oncogene · 2016Review
- Polo-Like Kinase 3 Appears Dispensable for Normal Retinal Development Despite Robust Embryonic Expression.PloS one · 2016Article
- Fancb deficiency impairs hematopoietic stem cell function.Scientific reports · 2015Article
- Understanding the Polo Kinase machine.Oncogene · 2015Review
- Abortive cell cycle events in the brains of scrapie-infected hamsters with remarkable decreases of PLK3/Cdc25C and increases of PLK1/cyclin B1.Molecular neurobiology · 2013Article
- SCF ubiquitin ligases in the maintenance of genome stability.Trends in biochemical sciences · 2012Article
- Coordinated expression of tristetraprolin post-transcriptionally attenuates mitogenic induction of the oncogenic Ser/Thr kinase Pim-1.PloS one · 2012Article
- Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints.Cellular signalling · 2011Article
- Article
- Pectenotoxin-2 from marine sponges: a potential anti-cancer agent-a review.Marine drugs · 2011Review
- Illumination of mitotic orchestra during cell division: a Polo view.Cellular signalling · 2011Review
- Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes.Oncogene · 2010Review
- Distinct pools of cdc25C are phosphorylated on specific TP sites and differentially localized in human mitotic cells.PloS one · 2010Article
- Interactions of prion protein with intracellular proteins: so many partners and no consequences?Cellular and molecular neurobiology · 2010Review
- Polo-like kinases: conservation and divergence in their functions and regulation.Nature reviews. Molecular cell biology · 2009Review
- Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation.Molecular and cellular biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Polo-like kinases (Plks) are key regulators of the cell cycle, especially in the G2 phase and mitosis. They are incorporated into signaling networks that regulate many aspects of the cell cycle, including but not limited to centrosome maturation and separation, mitotic entry, chromosome segregation, mitotic exit, and cytokinesis. The Plks have well conserved 30-amino-acid elements, designated polo boxes (PBs), located in their carboxyl-termini, which with their flanking regions constitute a functional Polo-box domain (PBD). Members of the Plk family exist in a variety of organisms including Polo in Drosophila melanogaster; Cdc5 in Saccharomyces cerevisiae; Plo1 in Schizosaccharomyces pombe; Plx1 in Xenopus laevis; and Plk1, Snk/Plk2, Fnk/Prk/Plk3, and Sak in mammals. Polo, Cdc5, and Plo1 are essential for viability. The Plks can be separated into two groups according to their functions. The first group (Polo, Cdc5, plo1, Plx1, and Plk1) primarily performs mitotic functions, whereas the second group (Plk2 and Plk3) appears to have additional functions during the G1, S, and G2 phases of the cell cycle. Several contributions to this issue will discuss different aspects of Plk involvement in cell-cycle regulation. This review, therefore, will focus on the role of Plk3 in regulating Cdc25 phosphatase function and its effect on the cell cycle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.