ReviewOncogene2005
Xenopus Polo-like kinase Plx1: a multifunctional mitotic kinase.
Review in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Translational control of cell growth and malignancy by the CPEBs.Nature reviews. Cancer · 2013Pooled it
- PLK1 maintains DNA methylation and cell viability by regulating phosphorylation-dependent UHRF1 protein stability.Cell death discovery · 2023Article
- An updated view on the centrosome as a cell cycle regulator.Cell division · 2022Review
- Regulation of polo-like kinase 1 by DNA damage and PP2A/B55α.Cell cycle (Georgetown, Tex.) · 2015Article
- Polo-like kinase-activating kinases: Aurora A, Aurora B and what else?Cell cycle (Georgetown, Tex.) · 2012Article
- Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation.Cell calcium · 2009Article
- An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.Nature cell biology · 2009Article
- Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs.Developmental biology · 2008Article
- Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry.Science (New York, N.Y.) · 2008Article
- Roles of Greatwall kinase in the regulation of cdc25 phosphatase.Molecular biology of the cell · 2008Article
- Plx1 is required for chromosomal DNA replication under stressful conditions.The EMBO journal · 2008Article
- Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.Molecular biology of the cell · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Xenopus Polo-like kinase Plx1 plays multiple roles in mitosis. Accumulating evidence shows that Plx1 is the trigger kinase for the G2/M transition that phosphorylates and activates the phosphatase Cdc25C, which subsequently dephosphorylates Cdc2/cyclin B and initiates a positive feedback loop between Cdc25C and Cdc2/cyclin B. Recent findings indicate that Plx1 itself is also in a positive feedback loop. It phosphorylates and activates the protein kinase xPlkk1, which itself then phosphorylates and further activates Plx1. Plx1 functions on the centrosome to promote bipolar spindle formation. Plx1 associates with the anaphase-promoting complex/cyclosome (APC/C) and is required to activate the APC/C for degradation of mitotic regulators required for sister chromatid separation and exit from mitosis. Plx1 is also required for cytokinesis and is localized on the midbody of the contractile ring. All known functions of Plx1 require not only its kinase activity but also an intact polo box domain in the C-terminus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.