ReviewNeurotoxicity research2004
Genetic and environmental factors interact to influence anxiety.
Review in Neurotoxicity research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Living and neighborhood environments and anxiety symptoms among older adults in Anhui, China: evidence from a cross-sectional study.BMC public health · 2025Article
- Contributing Factors to the Rise in Adolescent Anxiety and Associated Mental Health Disorders: A Narrative Review of Current Literature.Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc · 2025Review
- Dysregulated Gene Expression: A Candidate Mechanism for Anxiety Disorders.Journal of psychiatry and brain science · 2025Article
- Mitophagy in the basolateral amygdala mediates increased anxiety induced by aversive social experience.Neuron · 2021Article
- Microsecond-timescale simulations suggest 5-HT-mediated preactivation of the 5-HTProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Fearful dogs have increased plasma glutamine and γ-glutamyl glutamine.Scientific reports · 2018Article
- Anxiety-like behavior and other consequences of early life stress in mice with increased protein kinase A activity.Behavioural brain research · 2018Article
- Article
- Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging.Neuroscience and biobehavioral reviews · 2013Review
- mGluR₁,5 activation improves network asynchrony and GABAergic synapse attenuation in the amygdala: implication for anxiety-like behavior in DBA/2 mice.Molecular brain · 2012Article
- Social defeat: impact on fear extinction and amygdala-prefrontal cortical theta synchrony in 5-HTT deficient mice.PloS one · 2011Article
- The effect of enriched environment on the outcome of traumatic brain injury; a behavioral, proteomics, and histological study.Frontiers in neuroscience · 2011Article
- Stress and traumatic brain injury: a behavioral, proteomics, and histological study.Frontiers in neurology · 2011Article
- BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents.NeuroImage · 2010Article
- Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes.Molecular psychiatry · 2006Article
- Gene-environment interplay in neurogenesis and neurodegeneration.Neurotoxicity research · 2004Review
- Psychological distress in twins with urological symptoms.General hospital psychiatryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both genetic and environmental factors influence normal anxiety traits as well as anxiety disorders. In addition it is becoming increasingly clear that these factors interact to produce specific anxiety-related behaviors. For example, in humans and in monkeys mutations in the gene encoding for the serotonin transporter result in increased anxiety in adult life when combined with a stressful environment during development. Another recent example comes from twin studies suggesting that a small hippocampus can be a predisposing condition that renders individuals susceptible to post traumatic stress disorder. Such examples illustrate how specific mutations leading to abnormal brain development may increase vulnerability to environmental insults which may in turn lead to specific anxiety disorders.
Indexed as
Identifiers
15639782What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.