ArticleJournal of molecular evolution2004
Overlapping messages and survivability.
Article in Journal of molecular evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Human SRD5A1 as a case of gene expression indel-resistance in triple-coding region.Genome biology · 2026Article
- Gene Overlapping as a Modulator ofMicroorganisms · 2022Article
- Article
- New insights into the evolutionary features of viral overlapping genes by discriminant analysis.Virology · 2020Article
- Asymmetric evolution in viral overlapping genes is a source of selective protein adaptation.Virology · 2019Article
- Overlapping genes and the proteins they encode differ significantly in their sequence composition from non-overlapping genes.PloS one · 2018Article
- Mitochondrial dual-coding genes in Trypanosoma brucei.PLoS neglected tropical diseases · 2017Article
- Molecular characterisation of Porcine rubulavirus (PorPV) isolates from different outbreaks in Mexico.Virus genes · 2016Article
- Article
- The effect of gene overlapping on the rate of RNA virus evolution.Molecular biology and evolution · 2013Article
- Identification and characterization of a novel ubiquitous nucleolar protein 'NARR' encoded by a gene overlapping the rab34 oncogene.Nucleic acids research · 2011Article
- Why genes overlap in viruses.Proceedings. Biological sciences · 2010Article
- The evolution of genome compression and genomic novelty in RNA viruses.Genome research · 2007Article
- A genome-wide study of dual coding regions in human alternatively spliced genes.Genome research · 2006Article
- Modern mRNA proofreading and repair: clues that the last universal common ancestor possessed an RNA genome?Molecular biology and evolution · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phenomenon of overlapping of various sequence messages in genomes is a puzzle for evolutionary theoreticians, geneticists, and sequence researchers. The overlapping is possible due to degeneracy of the messages, in particular, degeneracy of codons. It is often observed in organisms with a limited size of genome, possessing polymerases of low fidelity. The most accepted view considers the overlapping as a mechanism to increase the amount of information per unit length. Here we present a model that suggests direct evolutionary advantage of the message overlapping. Two opposing drives are considered: (a) reduction in the amount of vulnerable points when the overlapping of two messages involves common critical points and (b) cumulative compromising cost of coexistence of messages at the same site. Over a broad range of conditions the reduction of the target size prevails, thus making the overlapping of messages advantageous.
Indexed as
Identifiers
15638463What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.