ArticleInfection and immunity1992
Interactions between conidia of Aspergillus fumigatus and human complement component C3.
Article in Infection and immunity, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed.
- Humoral Immunity Against Aspergillus fumigatus.Mycopathologia · 2023Review
- Protective role of host complement system inFrontiers in immunology · 2022Article
- Complement receptor 3 mediatesVirulence · 2021Article
- Aspergillus fumigatus Induces the Release of IL-8 and MCP-1 by Activating Nuclear Transcription Through Dectin-1 and CR3 Receptors in Alveolar Epithelial Cells.Current microbiology · 2021Article
- Differential Interactions of Serum and Bronchoalveolar Lavage Fluid Complement Proteins with Conidia of Airborne Fungal Pathogen Aspergillus fumigatus.Infection and immunity · 2020Article
- Local Activation of the Alternative Pathway of Complement System in Mycotic Keratitis Patient Tear.Frontiers in cellular and infection microbiology · 2020Article
- Enolase FromFrontiers in immunology · 2019Article
- Host Soluble Mediators: Defying the Immunological Inertness ofJournal of fungi (Basel, Switzerland) · 2017Review
- H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses.Immunology · 2015Article
- Article
- Role of ficolin-A and lectin complement pathway in the innate defense against pathogenic Aspergillus species.Infection and immunity · 2013Article
- Aspergillus-associated airway disease, inflammation, and the innate immune response.BioMed research international · 2013Review
- A mucormycosis case in a cirrhotic patient successfully treated with posaconazole and review of published literature.Mycopathologia · 2012Review
- Identification of fibrinogen-binding proteins of Aspergillus fumigatus using proteomic approach.Mycopathologia · 2012Article
- Article
- Complement Attack against Aspergillus and Corresponding Evasion Mechanisms.Interdisciplinary perspectives on infectious diseases · 2012Article
- Necessary and sufficient role for T helper cells to prevent fungal dissemination in allergic lung disease.Infection and immunity · 2011Article
- Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway.Frontiers in microbiology · 2011Article
- The crucial role of the Aspergillus fumigatus siderophore system in interaction with alveolar macrophages.Microbes and infection · 2010Article
- Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5.Infection and immunity · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation and deposition of C3 on Aspergillus fumigatus conidia have been previously demonstrated. This study investigated in further detail the interactions between complement component C3 and the conidia of A. fumigatus. Immunoblotting and 125I-C3 binding studies showed that C3 deposition was rapid (less than 15 min) and parallel to the formation of iC3b. Immunoblotting experiments identified a 54- to 58-kDa conidial protein which binds human complement component C3 and/or a C3 fragment(s). 125I labeling of the outer layer of the conidia demonstrated that this protein doublet was present on the surface of the spore. The further degradation of C3 to low-molecular-mass fragments (40, 37, and 30 kDa), in the absence of plasma, by intact living conidia and a preparation of the outer conidial wall layer indicated the ability of fungal components to cleave C3. These data suggest that interactions between conidia and C3 are not limited only to deposition via activation of the alternative complement pathway; they also include degradation of bound C3.
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