ArticleInfection and immunity1992
Delivery and expression of a heterologous antigen on the surface of streptococci.
Article in Infection and immunity, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Clinical and microbiological responses of volunteers to combined intranasal and oral inoculation with a Streptococcus gordonii carrier strain intended for future use as a group A streptococcus vaccine.Infection and immunity · 2005Trial
- A nisin-inducible chromosomal gene expression system based on ICE Tn5253 of Streptococcus pneumoniae, transferable among streptococci and enterococci.World journal of microbiology & biotechnology · 2024Article
- Vaccine Approaches To Protect against Group A Streptococcal Pharyngitis.Microbiology spectrum · 2019Review
- Genetics of Group A Streptococci.Microbiology spectrum · 2019Review
- Surface display of glycosylated Tyrosinase related protein-2 (TRP-2) tumour antigen on Lactococcus lactis.BMC biotechnology · 2015Article
- Novel Sample Preparation for Mass Spectral Analysis of Complex Biological Samples.Current proteomics · 2010Article
- Selection and characterization of a promoter for expression of single-copy recombinant genes in Gram-positive bacteria.BMC biotechnology · 2005Article
- Production of human papillomavirus type 16 E7 protein in Lactococcus lactis.Applied and environmental microbiology · 2002Article
- Erysipelothrix rhusiopathiae YS-1 as a live vaccine vehicle for heterologous protein expression and intranasal immunization of pigs.Infection and immunity · 2002Article
- Improved pattern for genome-based screening identifies novel cell wall-attached proteins in gram-positive bacteria.Infection and immunity · 2001Article
- Inactivation of the srtA gene in Streptococcus gordonii inhibits cell wall anchoring of surface proteins and decreases in vitro and in vivo adhesion.Infection and immunity · 2001Article
- Immunogenicity of the B monomer of Escherichia coli heat-labile toxin expressed on the surface of Streptococcus gordonii.Infection and immunity · 2000Article
- Display of polyhistidine peptides on the Escherichia coli cell surface by using outer membrane protein C as an anchoring motif.Applied and environmental microbiology · 1999Article
- Expression of Chlamydia psittaci- and human immunodeficiency virus-derived antigens on the cell surface of Lactobacillus fermentum BR11 as fusions to bspA.Infection and immunity · 1999Article
- Recombinant Staphylococcus strains as live vectors for the induction of neutralizing anti-diphtheria toxin antisera.Infection and immunity · 1999Article
- Staphylococcal surface display of immunoglobulin A (IgA)- and IgE-specific in vitro-selected binding proteins (affibodies) based on Staphylococcus aureus protein A.Applied and environmental microbiology · 1999Article
- Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope.Microbiology and molecular biology reviews : MMBR · 1999Review
- Surface display of the cholera toxin B subunit on Staphylococcus xylosus and Staphylococcus carnosus.Applied and environmental microbiology · 1997Article
- Development of a radioactive protein A-based assay for analysis of surface protein expression in gram-positive bacteria.Applied and environmental microbiology · 1997Article
- Display of heterologous proteins on the surface of microorganisms: from the screening of combinatorial libraries to live recombinant vaccines.Nature biotechnology · 1997Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We have developed a system in which a foreign antigen replaces nearly all of the surface-exposed region of the fibrillar M protein from Streptococcus pyogenes and is fused to the C-terminal attachment motif of the M molecule. The fusion protein is thus expressed on the surface of Streptococcus gordonii, a commensal organism of the oral cavity. The antigen chosen to be expressed within the context of the M6 molecule was the E7 protein (98 amino acids) of human papillomavirus type 16. Stable recombinant streptococci were obtained by integrating genetic constructs into the chromosome, exploiting in vivo homologous recombination. The M6-E7 fusion protein expressed on the S. gordonii surface was shown to be immunogenic in mice. This is the first step in the construction of recombinant live vaccines in which nonpathogenic streptococci as well as other gram-positive bacteria may be used as vectors to deliver heterologous antigens to the immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.