ArticleWorld journal of gastroenterology2005
Anti-HBV effect of liposome-encapsulated matrine in vitro and in vivo.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 45 citations in OpenAlex.
- Traditional Chinese Medicine in Chronic Hepatitis B: Integrating Antiviral Effects and Immune Modulation in the Context of T Cell Exhaustion.Drug design, development and therapy · 2026Review
- Sophora alopecuroides biflavones glycoside, isolated from Sophora alopecuroides, inhibits the secretion of hepatitis B virus surface antigen through direct interaction with its antigenic loop domain.Virology journal · 2025Article
- Metabolites from traditional Chinese botanical drugs with anti-hepatitis B virus activity - a review.Frontiers in pharmacology · 2024Review
- Target Discovery of Matrine against PRRSV in Marc-145 Cells via Activity-Based Protein Profiling.International journal of molecular sciences · 2023Article
- Novel protein kinase C phosphorylated kinase inhibitor-matrine suppresses replication of hepatitis B virus via modulating the mitogen-activated protein kinase signal.Bioengineered · 2022Article
- JNK signaling as a target for anticancer therapy.Pharmacological reports : PR · 2021Review
- Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway.Journal of translational medicine · 2018Article
- Matrine Is Identified as a Novel Macropinocytosis Inducer by a Network Target Approach.Frontiers in pharmacology · 2018Article
- Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells.Journal of experimental & clinical cancer research : CR · 2017Article
- Matrine induces cell cycle arrest and apoptosis with recovery of the expression of miR-126 in the A549 non-small cell lung cancer cell line.Molecular medicine reports · 2016Article
- Matrine-induced autophagy counteracts cell apoptosis via the ERK signaling pathway in osteosarcoma cells.Oncology letters · 2016Article
- ANTIVIRAL ACTIVITY OFAfrican journal of traditional, complementary, and alternative medicines : AJTCAM · 2016Article
- Effect of matrine on primary human hepatocytes in vitro.Cytotechnology · 2015Article
- TCM matrine inducescell arrest and apoptosis with recovery expression of the hepato-specific miR122a in human hepatocellular carcinomaHep G2cell line.International journal of clinical and experimental medicine · 2015Article
- Synthesis and biological evaluation of sophocarpinic acid derivatives as anti-HCV agents.Acta pharmaceutica Sinica. B · 2014Article
- Article
- Effect of oxymatrine on the replication cycle of hepatitis B virus in vitro.World journal of gastroenterology · 2010Article
- Tea polyphenols exerts anti-hepatitis B virus effects in a stably HBV-transfected cell line.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2009Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the anti-HBV effect of liposome-encapsulated matrine (Lip-M) in vitro and in vivo.
methods2.2.15 cell line was cultured in vitro to observe the effect of Lip-M and matrine on the secretion of HBsAg and HBeAg. The toxicity of Lip-M and matrine to 2.2.15 cell line was also studied by MTT method. In in vivo study, drug treatment experiment was carried out on the 13th day after ducks were infected with duck hepatitis B virus (DHBV). The ducks were randomly divided into 4 groups with 5-6 ducks in each group. Lip-M and matrine were given to DHBV-infected ducks respectively by gastric perfusion. Four groups were observed: group of Lip-M (20 mg/kg), group of Lip-M (10 mg/kg), group of matrine (20 mg/kg) and group of blank model. The drug was given once daily for 20 d continuously, and normal saline was used as control. The blood was drawn from the posterior tibial vein of all ducks before treatment (T(0)), after the medication for 5 (T5), 10 (T10), 15 (T15), 20 (T20) d and withdrawl of the drug for 3 d (P3). The serum samples were separated and stored at -70 degrees, DHBV-DNA was detected by the dot-blot hybridization.
resultsAfter addition of Lip-M and matrine to 2.2.15 cell line for eleven d, the median toxic concentration (TC50) of Lip-M and matrine was 7.29 mg/mL and 1.33 mg/mL respectively. The median concentration (IC50) of Lip-M to inhibit HBsAg and HBeAg expression was 0.078 mg/mL and 3.35 mg/mL respectively. The treatment index (TI) value of Lip-M for HBsAg and HBeAg was 93.46 and 2.17 respectively, better than that of matrine. The DHBV-infected duck model treatment test showed that the duck serum DHBV-DNA levels were markedly reduced in the group of Lip-M (20 mg/kg) after treated by gastric perfusion for 10, 15 and 20 d (0.43+/-0.22 vs 0.95+/-0.18, t = 4.70, P = 0.001<0.01.0.40+/-0.12 vs 0.95+/-0.18, t = 6.34, P = 0.000<0.01. 0.22+/-0.10 vs 0.95+/-0.18, t = 8.30, P = 0.000<0.01), compared to the group of matrine (20 mg/kg) (0.43+/-0.22 vs 0.79+/-0.19, t = 3.17, P = 0.01<0.05. 0.40+/-0.12 vs 0.73+/-0.24, t = 3.21, P = 0.009<0.05. 0.22+/-0.10 vs 0.55+/-0.32, t = 2.27, P = 0.046<0.05.), and the control(0.43+/-0.22 vs 0.98+/-0.29, t = 3.68, P = 0.005<0.01. 0.40+/-0.12 vs 0.97+/-0.30, t = 4.26, P = 0.002<0.01. 0.22+/-0.10 vs 0.95+/-0.27, t = 5.76, P = 0.000<0.01). After the treatment for 20 d and withdrawl of the drug for 3 d, duck serum DHBV-DNA level in the group of Lip-M (10 mg/kg) markedly reduced (0.56+/-0.26 vs 0.95+/-0.38, t = 5.26, P = 0.003<0.05. 0.55+/-0.25 vs 0.95+/-0.38, t = 5.52, P = 0.003<0.05), and the difference was significant as compared with the control (0.56+/-0.26 vs 0.95+/-0.27, t = 2.37, P = 0.042<0.05. 0.55+/-0.25 vs 0.89+/-0.18, t = 2.55, P = 0.031<0.05), but not significant as compared with the group of matrine (20 mg/kg). After withdrawl of the drug for 3 d, the levels of DHBV-DNA did not relapse in both groups of Lip-M.
conclusionLip-M can evidently inhibit the replication of hepatitis B virus in vitro and in vivo; its anti-HBV effect is better than that of matrine.
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