ArticleWorld journal of gastroenterology2005
Effect of lipopolysaccharide on diarrhea and gastrointestinal transit in mice: roles of nitric oxide and prostaglandin E2.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Effects of Macleaya Cordata Extract on LPS-Induced Intestinal Inflammation and Diarrhea via Modulation of Gut Microbiota.Animals : an open access journal from MDPI · 2026Article
- Evaluation of the Antidiarrheal Activity of 80% Methanolic Extract and Solvent Fractions of Calpurnia aurea (Ait.) Benth. (Fabaceae) Roots in Swiss Albino Mice.BioMed research international · 2026Article
- Effect of longevity genotype on acute phase response to a lipopolysaccharide challenge in dairy goats.PloS one · 2026Article
- Optimized detection of caspase-6 activation in a murine inflammation model to inform neurodegenerative disease therapies.PloS one · 2026Article
- Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis.iScience · 2025Article
- Calcium trafficking and gastrointestinal physiology following an acute lipopolysaccharide challenge in pigs.Journal of animal science · 2024Article
- Competitive Analysis of Rumen and Hindgut Microbiota Composition and Fermentation Function in Diarrheic and Non-Diarrheic Postpartum Dairy Cows.Microorganisms · 2023Article
- Effects ofAnimals : an open access journal from MDPI · 2023Article
- Lipopolysaccharide Tolerance Enhances Murine Norovirus Reactivation: An Impact of Macrophages Mainly Evaluated by Proteomic Analysis.International journal of molecular sciences · 2023Article
- Differences in the Intestinal Microbiome Associated with Diarrhea during Lenvatinib Treatment for Hepatocellular Carcinoma.Digestive diseases (Basel, Switzerland) · 2023Article
- Biomolecules Triggering Altered Food Intake during Pathogenic Challenge in Chicks.The journal of poultry science · 2023Review
- Evaluation ofMetabolism open · 2022Article
- Antidiarrheal and Antibacterial Activities ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Antidiarrheal Effect of 80% Methanol Extract and Fractions ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Anti-Shigellosis Activity ofBioMed research international · 2019Article
- Effects ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Lipopolysaccharide reduces food passage rate from the crop by a prostaglandin-independent mechanism in chickens.British poultry science · 2017Article
- Antimicrobial decision making for enteric diseases of cattle.The Veterinary clinics of North America. Food animal practice · 2015Review
- Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4/MD-2 receptor.BMC complementary and alternative medicine · 2014Article
- Comparison of mouse urinary metabolic profiles after exposure to the inflammatory stressors γ radiation and lipopolysaccharide.Radiation research · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effect of lipopolysaccharide (LPS) on the diarrheogenic activity, gastrointestinal transit (GIT), and intestinal fluid content and the possible role of nitric oxide (NO) and prostaglandin E2 (PGE2) in gastrointestinal functions of endotoxin-treated mice.
methodsDiarrheogic activity, GIT, and intestinal fluid content as well as nitric oxide and PGE2 products were measured after intraperitoneal administration of LPS in mice.
resultsLPS dose-dependently accumulated abundant fluid into the small intestine, induced diarrhea, but decreased the GIT. Both nitric oxide and PGE2 were found to increase in LPS-treated mice. Western blot analysis indicated that LPS significantly induced the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 in mice intestines. Pretreatment with N(G)-nitro-L-arginine-methyl ester (L-NAME, a non-selective NOS inhibitor) or indomethacin (an inhibitor of prostaglandin synthesis) significantly attenuated the effects of LPS on the diarrheogenic activity and intestine content, but reversed the GIT.
conclusionThe present study suggests that the pathogenesis of LPS treatment may mediate the stimulatory effect of LPS on nitric oxide and PGE2 production and NO/prostaglandin pathway may play an important role on gastrointestinal function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.