SynthesisWorld journal of gastroenterology2005
Relationship between metabolic enzyme polymorphism and colorectal cancer.
Synthesis in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 8 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Unveiling the link: Evaluating MTHFR gene polymorphisms and colorectal cancer risk through meta-analysis.PloS one · 2025Pooled it
- Associations between CYP1A1 rs1048943 A > G and rs4646903 T > C genetic variations and colorectal cancer risk: Proof from 26 case-control studies.Oncotarget · 2016Pooled it
- MTHFR genetic polymorphisms may contribute to the risk of chronic myelogenous leukemia in adults: a meta-analysis of 12 genetic association studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- GSTM1 and GSTT1 polymorphisms and colorectal cancer risk in Chinese population: a meta-analysis.International journal of colorectal disease · 2012Pooled it
- Possible association of NAT2 polymorphism with laryngeal cancer risk: an evidence-based meta-analysis.Journal of cancer research and clinical oncology · 2011Pooled it
- An updating meta-analysis of the glutathione S-transferase T1 polymorphisms and colorectal cancer risk: a HuGE review.International journal of colorectal disease · 2010Pooled it
- GSTM1 and GSTT1 polymorphisms and nasopharyngeal cancer risk: an evidence-based meta-analysis.Journal of experimental & clinical cancer research : CR · 2009Pooled it
- Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis.Journal of human genetics · 2006Pooled it
- Sequence Polymorphism in Xenobiotic Metabolising Genes in Iraqi Colorectal Cancer Patients.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Article
- Genetic variations in genes of metabolic enzymes predict postoperational prognosis of patients with colorectal cancer.Molecular cancer · 2015Article
- NAT1 polymorphisms and cancer risk: a systematic review and meta-analysis.International journal of clinical and experimental medicine · 2015Article
- A systemic review of glutathione S-transferase P1 Ile105Val polymorphism and colorectal cancer risk.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2014Article
- Association of Glutathione-S-Transferase (GSTM1 and GSTT1) and FTO Gene Polymorphisms with Type 2 Diabetes Mellitus Cases in Northern India.Balkan journal of medical genetics : BJMG · 2014Article
- CYP1A1, GSTM1, GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men.World journal of gastroenterology · 2013Article
- Article
- A comparison of approaches for association studies of polymorphisms and colorectal cancer risk.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2012Article
- The polymorphisms in methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase, and the risk of colorectal cancer.International journal of biological sciences · 2012Article
- Polymorphisms in heterocyclic aromatic amines metabolism-related genes are associated with colorectal adenoma risk.International journal of molecular epidemiology and genetics · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo clarify the influence of genetic polymorphisms on colorectal cancer.
methodsThe results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. Mantel-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied in processing the data.
resultsMeta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)-rapid acetylator phenotype and genotye (pooled OR = 1.08) and NAT2-rapid acetylator phenotype (pooled OR = 1.15) had a significantly increased risk for colorectal cancer (P<0.05), other genotypes like GSTM1 deletion, GSTP1 1le105Val, NAT1*10, NAT2-rapid acetylator genotype CYP1A1 L1e462Val, CYP1A1 MspI*C, MTHFR C677T and MTR A2759G had no significant relationship with colorectal cancer (P>0.05).
conclusionRisks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTT1 deletion, NAT2-rapid acetylator phenotype and genotye and NAT2-rapid acetylator phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.