ReviewMedicinal research reviews2005
The role of small RNAs in human diseases: potential troublemaker and therapeutic tools.
Review in Medicinal research reviews, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 64 citations in OpenAlex.
- miRNA-Based Technologies in Cancer Therapy.Journal of personalized medicine · 2023Review
- Identification of MiRNA-Disease Associations Based on Information of Multi-Module and Meta-Path.Molecules (Basel, Switzerland) · 2022Article
- Do small RNAs unlock the below ground microbiome-plant interaction mystery?Frontiers in molecular biosciences · 2022Review
- Article
- Exploration of the regulation and control mechanisms of miR-145 in trophoblast cell proliferation and invasion.Experimental and therapeutic medicine · 2018Article
- Bioinformatic tools for microRNA dissection.Nucleic acids research · 2016Review
- Bioinformatics approach to predict target genes for dysregulated microRNAs in hepatocellular carcinoma: study on a chemically-induced HCC mouse model.BMC bioinformatics · 2015Article
- Microarray-based analysis of gene regulation by transcription factors and microRNAs in glioma.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- Effect of GPE-AGT nanoparticle shRNA transfection system mediated RNAi on early atherosclerotic lesion.International journal of clinical and experimental pathology · 2012Article
- Application of RNA interference in treating human diseases.Journal of genetics · 2010Review
- Design and evaluation of a panel of single-nucleotide polymorphisms in microRNA genomic regions for association studies in human disease.European journal of human genetics : EJHG · 2010Article
- MicroRNA profile analysis of human prostate cancers.Cancer gene therapy · 2009Article
- Modulation of miRNA activity in human cancer: a new paradigm for cancer gene therapy?Cancer gene therapy · 2008Review
- Use of herpes simplex virus type 1-based amplicon vector for delivery of small interfering RNA.Gene therapy · 2007Article
- A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs.Nucleic acids research · 2007Article
- Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?Gene therapy · 2006Review
- The therapeutic potential of RNA interference.FEBS letters · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small RNAs, including short interfering RNAs (siRNAs) and microRNAs (miRNAs), are ubiquitous, versatile repressors of gene expression in plants, animals, and many fungi. They can trigger destruction of homologous mRNA or inhibition of cognate mRNA translation and play an important role in maintaining the stable state of chromosome structure and regulating the expression of protein-coding genes. Furthermore, the recent research showed that there exists close relationship between small RNAs and human diseases. Several human diseases have surfaced in which miRNAs or their machinery might be implicated, such as some neurological diseases and cancers. The specificity and potency of small RNAs suggest that they might be promising as therapeutic agents. This article will review the role of small RNAs in some human diseases etiology and investigations of taking siRNAs as therapeutic tools for treating viral infection, cancer, and other diseases. We also discuss the potential of miRNAs in gene therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.