ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2005
Accumulation and loss of extracellular matrix during shear stress-mediated intimal growth and regression in baboon vascular grafts.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Stenosis in Mature Arteriovenous Fistulas Characterized by Contractile Smooth Muscle Cells and Versican.Kidney international reports · 2026Article
- ADAMTS-5: A difficult teenager turning 20.International journal of experimental pathology · 2020Review
- Location-Specific Comparison Between a 3D In-Stent Restenosis Model and Micro-CT and Histology Data from Porcine In Vivo Experiments.Cardiovascular engineering and technology · 2019Article
- A simple ex vivo model of human renal allograft preservation using the gonadal vein.Annals of the Royal College of Surgeons of England · 2019Article
- A role for proteoglycans in vascular disease.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- Versican and the regulation of cell phenotype in disease.Biochimica et biophysica acta · 2014Review
- Versican and the control of inflammation.Matrix biology : journal of the International Society for Matrix Biology · 2014Review
- Article
- Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease.Developmental biology · 2011Article
- Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling.The Journal of biological chemistry · 2011Article
- A link between smooth muscle cell death and extracellular matrix degradation during vascular atrophy.Journal of vascular surgery · 2011Article
- ADAMTS proteases: key roles in atherosclerosis?Journal of molecular medicine (Berlin, Germany) · 2010Review
- Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies.Matrix biology : journal of the International Society for Matrix Biology · 2010Article
- Cell death-associated ADAMTS4 and versican degradation in vascular tissue.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- Effects of external wrapping and increased blood flow on atrophy of the baboon iliac artery.Journal of vascular surgery · 2008Article
- Induction of vascular atrophy as a novel approach to treating restenosis. A review.Journal of vascular surgery · 2008Review
- Versican degradation and vascular disease.Trends in cardiovascular medicine · 2006Review
- Bone morphogenetic protein 4: potential regulator of shear stress-induced graft neointimal atrophy.Journal of vascular surgery · 2006Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The composition of extracellular matrix during growth and regression of the neointima was analyzed during healing in a baboon aorto-iliac polytetrafluoroethylene graft. Graft neointimal thickening can be modulated by altering blood flow by construction of downstream arteriovenous fistulas. Normal flow with normal shear stress induces neointimal thickening, whereas high flow with high shear stress upstream of a fistula induces regression of established neointima. The neointima formed under normal shear stress is enriched in hyaluronan and proteoglycans, particularly versican. On the other hand, the neointima near the graft material is enriched in collagen and biglycan. Neointimal regression in response to high shear stress is associated with a loss of proteoglycans as detected by histochemical staining. Immunostaining with an antibody against an ADAMTS cleavage neoepitope of versican increases after switching to high flow, although immunostaining for versican core protein is not appreciably changed by high flow. The present data demonstrate that the graft neointima is enriched with proteoglycans, particularly versican and hyaluronan, as well as collagen, and there is a differential distribution of each. Neointimal atrophy occurs with an apparent loss of proteoglycans and evidence of versican degradation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.