Statins for atherosclerosis--as good as it gets?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Association of Preadmission Statin Use and Mortality in Critically Ill Patients: A Meta-Analysis of Cohort Studies.Frontiers in medicine · 2021
   Pooled it
2. Early High-dosage Atorvastatin Treatment Improved Serum Immune-inflammatory Markers and Functional Outcome in Acute Ischemic Strokes Classified as Large Artery Atherosclerotic Stroke: A Randomized Trial.Medicine · 2016
   Trial
3. MicroRNA-30c analog C2 decreases plasma cholesterol and atherosclerosis without causing liver injury in preclinical studies.Nature communications · 2026
   Article
4. HMG-CoA Reductase Inhibitors for Traumatic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
   Review
5. Bmal1 regulates production of larger lipoproteins by modulating cAMP-responsive element-binding protein H and apolipoprotein AIV.Hepatology (Baltimore, Md.) · 2022
   Article
6. Nanotechnological approach to delivering nutraceuticals as promising drug candidates for the treatment of atherosclerosis.Drug delivery · 2021
   Review
7. New perspectives on treatment strategies for patient with acute myeloid leukemia and complex karyotype abnormalities after percutaneous coronary intervention: A case report.Medicine · 2019
   Article
8. The beneficial effects of HMG-CoA reductase inhibitors in the processes of neurodegeneration.Metabolic brain disease · 2017
   Review
9. Protective Effects of Statins in Cancer: Should They Be Prescribed for High-Risk Patients?Current atherosclerosis reports · 2016
   Review
10. Relation of statin use with non-melanoma skin cancer: Prospective results from the Women's Health Initiative.Women's health (London, England) · 2016
    Article
11. MicroRNA-30c Mimic Mitigates Hypercholesterolemia and Atherosclerosis in Mice.The Journal of biological chemistry · 2016
    Article
12. Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients.The Journal of clinical investigation · 2014
    Article
13. A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors.Oncotarget · 2013
    Article
14. Lovastatin dose-dependently potentiates the pro-inflammatory activity of lipopolysaccharide both in vitro and in vivo.Journal of cardiovascular translational research · 2013
    Article
15. Attenuation by statins of membrane raft-redox signaling in coronary arterial endothelium.The Journal of pharmacology and experimental therapeutics · 2013
    Article
16. Simvastatin enhances protection against Listeria monocytogenes infection in mice by counteracting Listeria-induced phagosomal escape.PloS one · 2013
    Article
17. Inhibition of interferon-beta responses in multiple sclerosis immune cells associated with high-dose statins.Archives of neurology · 2012
    Article
18. A practical approach to lipid management in the elderly.The journal of nutrition, health & aging · 2011
    Article
19. Anti-inflammatory effect of fluvastatin on IL-8 production induced by Pseudomonas aeruginosa and Aspergillus fumigatus antigens in cystic fibrosis.PloS one · 2011
    Article
20. Preadmission statin use and one-year mortality among patients in intensive care - a cohort study.Critical care (London, England) · 2010
    Article

Corrections and comments

• Comment on
  C-reactive protein levels and outcomes after statin therapy.2005
• Comment on
  Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease.2005

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as