ArticleMolecular biology of the cell2005
EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The dystrobrevin-binding protein 1 gene: features and networks.Molecular psychiatry · 2009Pooled it
- Plasma Exosomes Associated with Growth Divergence in High-Density Cultured Grass Carp (International journal of molecular sciences · 2026Article
- EBAG9-deficient mice display decreased bone mineral density with suppressed autophagy.iScience · 2024Article
- HIV-1 Vpr protein impairs lysosome clearance causing SNCA/alpha-synuclein accumulation in neurons.Autophagy · 2021Article
- SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages.Autophagy · 2017Article
- Host protein Snapin interacts with human cytomegalovirus pUL130 and affects viral DNA replication.Journal of biosciences · 2016Article
- Mutations in the BLOC-1 subunits dysbindin and muted generate divergent and dosage-dependent phenotypes.The Journal of biological chemistry · 2014Article
- Modulation of the cellular distribution of human cytomegalovirus helicase by cellular factor Snapin.Journal of virology · 2013Article
- LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25.Experimental & molecular medicine · 2013Article
- Transmembrane prostatic acid phosphatase (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma.PloS one · 2013Article
- Akt3 controls vascular endothelial growth factor secretion and angiogenesis in ovarian cancer cells.International journal of cancer · 2012Article
- Human cytomegalovirus primase UL70 specifically interacts with cellular factor Snapin.Journal of virology · 2011Article
- Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma.Acta pharmacologica Sinica · 2010Review
- Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.Nature reviews. Immunology · 2010Review
- Tumor-associated, estrogen receptor-related antigen EBAG9: linking intracellular vesicle trafficking, immune homeostasis, and malignancy.Molecular interventions · 2009Article
- The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.The Journal of clinical investigation · 2009Article
- EBAG9 tempers lymphocyte killing activity.The Journal of clinical investigation · 2009Article
- Snapin associates with late endocytic compartments and interacts with late endosomal SNAREs.Bioscience reports · 2009Article
- A data-mining approach to rank candidate protein-binding partners-The case of biogenesis of lysosome-related organelles complex-1 (BLOC-1).Journal of inherited metabolic disease · 2009Article
- Modeling of the potential coiled-coil structure of snapin protein and its interaction with SNARE complex.Bioinformation · 2006Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulated exocytosis is subject to several modulatory steps that include phosphorylation events and transient protein-protein interactions. The estrogen receptor-binding fragment-associated gene9 (EBAG9) gene product was recently identified as a modulator of tumor-associated O-linked glycan expression in nonneuronal cells; however, this molecule is expressed physiologically in essentially all mammalian tissues. Particular interest has developed toward this molecule because in some human tumor entities high expression levels correlated with clinical prognosis. To gain insight into the cellular function of EBAG9, we scored for interaction partners by using the yeast two-hybrid system. Here, we demonstrate that EBAG9 interacts with Snapin, which is likely to be a modulator of Synaptotagmin-associated regulated exocytosis. Strengthening of this interaction inhibited regulated secretion of neuropeptide Y from PC12 cells, whereas evoked neurotransmitter release from hippocampal neurons remained unaltered. Mechanistically, EBAG9 decreased phosphorylation of Snapin; subsequently, association of Snapin with synaptosome-associated protein of 25 kDa (SNAP25) and SNAP23 was diminished. We suggest that the occurrence of SNAP23, Snapin, and EBAG9 also in nonneuronal cells might extend the modulatory role of EBAG9 to a broad range of secretory cells. The conjunction between EBAG9 and Snapin adds an additional layer of control on exocytosis processes; in addition, mechanistic evidence is provided that inhibition of phosphorylation has a regulatory function in exocytosis.
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