ArticleJournal of clinical microbiology2005
Propionibacterium acnes types I and II represent phylogenetically distinct groups.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed, 199 citations in OpenAlex.
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- The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions.Acta pharmaceutica Sinica. B · 2024Review
- Association of different cell types and inflammation in early acne vulgaris.Frontiers in immunology · 2024Review
- Whole genome sequencing distinguishes skin colonizing from infection-associatedFrontiers in cellular and infection microbiology · 2024Article
- Comparative Genomic Analysis ofMicroorganisms · 2023Article
- Phenotypic and Genotypic Characterization ofMicroorganisms · 2023Article
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- Acne Vulgaris, Atopic Dermatitis and Rosacea: The Role of the Skin Microbiota-A Review.Biomedicines · 2022Review
- Microbiological Characterization ofAntibiotics (Basel, Switzerland) · 2022Article
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- Frequency and characteristics of bacterial and viral low-grade infections of the intervertebral discs: a prospective, observational study.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2022Observational
- Engineering selectivity of Cutibacterium acnes phages by epigenetic imprinting.PLoS pathogens · 2022Article
- Different phylotypes of Cutibacterium acnes cause different modic changes in intervertebral disc degeneration.PloS one · 2022Article
- Amplicon-Based Next-Generation Sequencing as a Diagnostic Tool for the Detection of Phylotypes ofFrontiers in microbiology · 2022Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although two phenotypes of the opportunistic pathogen Propionibacterium acnes (types I and II) have been described, epidemiological investigations of their roles in different infections have not been widely reported. Using immunofluorescence microscopy with monoclonal antibodies (MAbs) QUBPa1 and QUBPa2, specific for types I and II, respectively, we investigated the prevalences of the two types among 132 P. acnes isolates. Analysis of isolates from failed prosthetic hip implants (n = 40) revealed approximately equal numbers of type I and II organisms. Isolates from failed prosthetic hip-associated bone (n = 6) and tissue (n = 38) samples, as well as isolates from acne (n = 22), dental infections (n = 8), and skin removed during surgical incision (n = 18) were predominately of type I. A total of 11 (8%) isolates showed atypical MAb labeling and could not be conclusively identified. Phylogenetic analysis of P. acnes by nucleotide sequencing revealed the 16S rRNA gene to be highly conserved between types I and II. In contrast, sequence analysis of recA and a putative hemolysin gene (tly) revealed significantly greater type-specific polymorphisms that corresponded to phylogenetically distinct cluster groups. All 11 isolates with atypical MAb labeling were identified as type I by sequencing. Within the recA and tly phylogenetic trees, nine of these isolates formed a cluster distinct from other type I organisms, suggesting a further phylogenetic subdivision within type I. Our study therefore demonstrates that the phenotypic differences between P. acnes types I and II reflect deeper differences in their phylogeny. Furthermore, nucleotide sequencing provides an accurate method for identifying the type status of P. acnes isolates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.