ArticleJournal of clinical microbiology2005
Characterization of ermB gene transposition by Tn1545 and Tn917 in macrolide-resistant Streptococcus pneumoniae isolates.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Serotype replacement and mobile genetic elements inMicrobial genomics · 2025Pooled it
- Genomic and molecular dynamics analysis of mefA-encoded macrolide efflux protein from Tn2009 and Tn2010 in Streptococcus pneumoniae.Molecular genetics and genomics : MGG · 2026Article
- Antimicrobial Susceptibility Profiles ofAntibiotics (Basel, Switzerland) · 2025Article
- Pre-vaccination carriage prevalence of Streptococcus pneumoniae serotypes among internally displaced people in Somaliland: a cross-sectional study.Pneumonia (Nathan Qld.) · 2024Article
- Article
- The Genetic Landscape of Antimicrobial Resistance Genes inAntibiotics (Basel, Switzerland) · 2024Article
- Dissemination and characteristics of high-level erythromycin-resistantCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023Article
- Genomic Characterization ofFrontiers in microbiology · 2022Article
- Phylogeography and resistome of pneumococcal meningitis in West Africa before and after vaccine introduction.Microbial genomics · 2021Article
- Antibiotic Resistance Genes in Antibiotic-Free Chicken Farms.Antibiotics (Basel, Switzerland) · 2020Article
- Genomics of high molecular weight plasmids isolated from an on-farm biopurification system.Scientific reports · 2016Article
- Effect of Tulathromycin on Colonization Resistance, Antimicrobial Resistance, and Virulence of Human Gut Microbiota in Chemostats.Frontiers in microbiology · 2016Article
- Mechanisms and impact of genetic recombination in the evolution of Streptococcus pneumoniae.Computational and structural biotechnology journal · 2015Review
- Resistance determinants and their association with different transposons in the antibiotic-resistant Streptococcus pneumoniae.BioMed research international · 2015Article
- Plasmid metagenome reveals high levels of antibiotic resistance genes and mobile genetic elements in activated sludge.PloS one · 2011Article
- New composite genetic element of the Tn916 family with dual macrolide resistance genes in a Streptococcus pneumoniae isolate belonging to clonal complex 271.Antimicrobial agents and chemotherapy · 2009Article
- Genetic elements responsible for erythromycin resistance in streptococci.Antimicrobial agents and chemotherapy · 2009Review
- Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation.Antimicrobial agents and chemotherapy · 2008Article
- Telithromycin-nonsusceptible clinical isolates of Streptococcus pneumoniae from Europe.Antimicrobial agents and chemotherapy · 2006Article
- Bacterial repetitive extragenic palindromic sequences are DNA targets for Insertion Sequence elements.BMC genomics · 2006Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Streptococcus pneumoniae, the ermB gene is carried by transposons, such as Tn917 and Tn1545. This study investigated the relationship between macrolide resistance and the presence of the ermB gene on Tn917 or Tn1545 in 84 Japanese pneumococcal isolates. Macrolide-resistant strains were classified into two groups as follows. Group 1 (19 strains) showed a tendency to high resistance to erythromycin (MIC at which 50% of isolates are inhibited, 4 mg/liter; MIC at which 90% of isolates are inhibited [MIC(90)], 128 mg/liter) but susceptibility to rokitamycin (MIC(90), 1 mg/liter), with the ermB gene located on Tn1545. Group 2 (65 strains) showed a tendency to high resistance to both antibiotics (MIC(90)s for both erythromycin and rokitamycin, >128 mg/liter), with the ermB gene located on Tn917. There were no strains with constitutive macrolide resistance in either group. All of the strains in group 2 had a deletion in the promoter region of ermB and an insertion of the TAAA motif in the leader peptide. The results of pulsed-field gel electrophoresis and serogrouping showed that Tn1545 spread clonally while Tn917 spread both horizontally and clonally. In conclusion, in Japanese macrolide-resistant S. pneumoniae isolates, the ermB gene is carried and spread primarily by Tn917.
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