ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Direct and indirect inhibition by catecholamines of hypocretin/orexin neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 124 citations in OpenAlex.
- Methamphetamine potentiates the use of outcome-specific associations via a hypothalamic-dopamine circuit.Neuron · 2026Article
- Nucleus of the solitary tract regulation of cue-induced appetitive behaviors via midbrain dopamine neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Hypothalamic control of arousal.Reviews in endocrine & metabolic disorders · 2026Review
- Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner.eLife · 2024Article
- The NaeLife · 2024Article
- The NabioRxiv : the preprint server for biology · 2023Article
- Natural locus coeruleus dynamics during feeding.Science advances · 2022Article
- Article
- Daily Fluctuation of Orexin Neuron Activity and Wiring: The Challenge of "Chronoconnectivity".Frontiers in pharmacology · 2018Review
- Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via βFrontiers in cellular neuroscience · 2017Article
- An integrated modelling framework for neural circuits with multiple neuromodulators.Journal of the Royal Society, Interface · 2017Article
- Sleep problems and hypothalamic dopamine D3 receptor availability in Parkinson disease.Neurology · 2016Article
- Adrenoceptor-Mediated Post- and Pre-Synaptic Regulations of the Reticulospinal Neurons in Rat Caudal Pontine Reticular Nucleus.Molecular neurobiology · 2016Article
- The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Hypocretins, Neural Systems, Physiology, and Psychiatric Disorders.Current psychiatry reports · 2016Review
- The Neurobiology of Sleep and Wakefulness.The Psychiatric clinics of North America · 2015Review
- Orexin-A enhances feeding in male rats by activating hindbrain catecholamine neurons.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Concentration-dependent activation of dopamine receptors differentially modulates GABA release onto orexin neurons.The European journal of neuroscience · 2015Article
- Neural circuit interactions between the dorsal raphe nucleus and the lateral hypothalamus: an experimental and computational study.PloS one · 2014Article
- Wake-promoting actions of noradrenergic α1 - and β-receptors within the lateral hypothalamic area.The European journal of neuroscience · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hypothalamic hypocretin enhances arousal, similar to the actions of norepinephrine (NE). The physiological actions of NE were examined in hypocretin neurons identified by selective green fluorescent protein expression in transgenic mouse hypothalamic slices using whole-cell recording. NE induced an outward current, inhibited spike frequency, and hyperpolarized hypocretin neurons dose dependently. Similar actions were evoked by the selective alpha2 adrenergic agonist clonidine. The alpha2 antagonist idazoxan increased spike frequency, suggesting tonic NE-mediated inhibition. The NE-induced current was inwardly rectified, and the reversal potential was dependent on external potassium concentration; it was blocked by barium in the bath and by GTP-gamma-S in the pipette, suggesting activation of a G-protein inward rectifying K+ (GIRK) current. NE and clonidine decreased calcium currents evoked by depolarizing voltage steps. The selective alpha1 adrenergic agonist phenylephrine had no effect on membrane potential but did increase IPSC frequency; miniature IPSC frequency was also increased, in some cells without any effect on amplitude, suggesting a facilitative presynaptic action at alpha1 receptors on GABAergic axons that innervate hypocretin neurons. NE therefore inhibits hypocretin neurons directly through two mechanisms: activation of a GIRK current, depression of calcium currents, and indirectly through increased inhibitory GABA input. Similar to NE, dopamine and epinephrine reduced or blocked spikes and, in the presence of TTX, showed direct hyperpolarizing actions. The action of dopamine was blocked by the D2 receptor antagonist eticlopride, whereas a D1/5 antagonist had no effect. These data suggest that catecholamines evoke strong inhibitory actions on hypocretin neurons and suggest negative feedback from catecholamine cells that may be excited by hypocretin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.