ReviewSpringer seminars in immunopathology2005
Human innate B cells: a link between host defense and autoimmunity?
Review in Springer seminars in immunopathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 78 citations in OpenAlex.
- Marginal-Zone B-Cells Are Main Producers of IgM in Humans, and Are Reduced in Patients With Autoimmune Vasculitis.Frontiers in immunology · 2018Trial
- Broad responses to chemical adducts shape the natural antibody repertoire in early infancy.Science advances · 2023Article
- Human VH4-34 antibodies derived from B1 cells are more frequently autoreactive than VH4-34 antibodies derived from memory cells.Frontiers in immunology · 2023Article
- The Role of B Lymphocyte Subsets in Adipose Tissue Development, Metabolism, and Aging.Comprehensive Physiology · 2022Article
- Fish Lymphocytes: An Evolutionary Equivalent of Mammalian Innate-Like Lymphocytes?Frontiers in immunology · 2018Review
- Antigen receptor stereotypy in chronic lymphocytic leukemia.Leukemia · 2017Review
- Review
- B cells in chronic obstructive pulmonary disease: moving to center stage.American journal of physiology. Lung cellular and molecular physiology · 2016Review
- Impaired immunological synapse in sperm associated antigen 6 (SPAG6) deficient mice.Scientific reports · 2016Article
- Cytokine and Growth Factor Activation In Vivo and In Vitro after Spinal Cord Injury.Mediators of inflammation · 2016Review
- Natural and adaptive IgM antibodies in the recognition of tumor-associated antigens of breast cancer (Review).Oncology reports · 2015Review
- Polychromatic flow cytometry in evaluating rheumatic disease patients.Arthritis research & therapy · 2015Review
- Primary cold agglutinin-associated lymphoproliferative disease: a B-cell lymphoma of the bone marrow distinct from lymphoplasmacytic lymphoma.Haematologica · 2014Article
- Article
- 9G4+ autoantibodies are an important source of apoptotic cell reactivity associated with high levels of disease activity in systemic lupus erythematosus.Arthritis and rheumatism · 2013Article
- Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- 9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity.PloS one · 2012Article
- Article
- B cells in autoimmunity.Arthritis research & therapy · 2009Review
- Systemic onset juvenile rheumatoid arthritis presenting with absence of B lymphocytes.Rheumatology international · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
B cells play a variety of immunoregulatory roles through their antigen-presentation ability and through cytokine and chemokine production. Innate immune activation of B cells may play a beneficial role through the generation of natural cross-reactive antibodies, by maintaining B cell memory and by exercising immunomodulatory functions that may provide protection against autoimmunity. In this article, we review human B cell populations and their functional properties, with a particular focus on a population of inherently autoreactive B cells, which seem to play an important physiological role in innate immunity, but which, if selected into adaptive immune responses, appear to become pathogenic agents in systemic lupus erythematosus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.