ArticleThe Journal of biological chemistry2005
Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors.
Article in The Journal of biological chemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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Who cites it
44 citing papers in PubMed, 66 citations in OpenAlex.
- NCOR1 and NCOR2 Exhibit Distinct Cellular and Transcriptomic Signatures in Human Abdominal Aortic Aneurysm.Biomedicines · 2026Article
- NOVA1 prevents overactivation of the unfolded protein response and facilitates chromatin access during human white adipogenesis.Nucleic acids research · 2023Article
- Review
- The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis.Nature communications · 2021Article
- A cell type-specific expression map of NCoR1 and SMRT transcriptional co-repressors in the mouse brain.The Journal of comparative neurology · 2020Article
- Specific ablation of the NCoR corepressor δ splice variant reveals alternative RNA splicing as a key regulator of hepatic metabolism.PloS one · 2020Article
- Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals.BMC research notes · 2019Article
- BQ323636.1, a Novel Splice Variant toClinical cancer research : an official journal of the American Association for Cancer Research · 2018Article
- The actions of thyroid hormone signaling in the nucleus.Molecular and cellular endocrinology · 2017Review
- Corepressor diversification by alternative mRNA splicing is species specific.BMC evolutionary biology · 2016Article
- Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling.Molecular and cellular endocrinology · 2015Article
- Short linear motif acquisition, exon formation and alternative splicing determine a pathway to diversity for NCoR-family co-repressors.Open biology · 2015Article
- Molecular mechanisms of transcriptional control by Rev-erbα: An energetic foundation for reconciling structure and binding with biological function.Protein science : a publication of the Protein Society · 2015Article
- Article
- The ability of thyroid hormone receptors to sense t4 as an agonist depends on receptor isoform and on cellular cofactors.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor.Molecular and cellular biology · 2014Article
- Epigenetic distortion to VDR transcriptional regulation in prostate cancer cells.The Journal of steroid biochemistry and molecular biology · 2013Review
- Emerging roles of the corepressors NCoR1 and SMRT in homeostasis.Genes & development · 2013Review
- Function of alternative splicing.Gene · 2013Review
- Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns.Carcinogenesis · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many eukaryotic transcription factors are bimodal in their regulatory properties and can both repress and activate expression of their target genes. These divergent transcriptional properties are conferred through recruitment of auxiliary proteins, denoted coactivators and corepressors. Repression plays a particularly critical role in the functions of the nuclear receptors, a large family of ligand-regulated transcription factors involved in metazoan development, differentiation, reproduction, and homeostasis. The SMRT corepressor interacts directly with nuclear receptors and serves, in turn, as a platform for the assembly of a larger corepressor complex. We report here that SMRT is expressed in cells by alternative mRNA splicing to yield two distinct variants or isoforms. We designate these isoforms SMRTalpha and SMRTtau and demonstrate that these isoforms have significantly different affinities for different nuclear receptors. These isoforms are evolutionarily conserved and are expressed in a tissue-specific manner. Our results suggest that differential mRNA splicing serves to customize corepressor function in different cells, allowing the transcriptional properties of nuclear receptors to be adapted to different contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.