ArticleMolecular and cellular biology2005
The histone chaperone anti-silencing function 1 is a global regulator of transcription independent of passage through S phase.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
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- Oncogenic lncRNAs alter epigenetic memory at a fragile chromosomal site in human cancer cells.Science advances · 2022Article
- Rap1-mediated nucleosome displacement can regulate gene expression in senescent cells without impacting the pace of senescence.Aging cell · 2020Article
- Molecular basis of Tousled-Like Kinase 2 activation.Nature communications · 2018Article
- Fly Fishing for Histones: Catch and Release by Histone Chaperone Intrinsically Disordered Regions and Acidic Stretches.Journal of molecular biology · 2017Review
- The Candida albicans Histone Acetyltransferase Hat1 Regulates Stress Resistance and Virulence via Distinct Chromatin Assembly Pathways.PLoS pathogens · 2015Article
- Nuclear FKBPs, Fpr3 and Fpr4 affect genome-wide genes transcription.Molecular genetics and genomics : MGG · 2014Article
- Genome-wide mapping of yeast histone chaperone anti-silencing function 1 reveals its role in condensin binding with chromatin.PloS one · 2014Article
- A compendium of nucleosome and transcript profiles reveals determinants of chromatin architecture and transcription.PLoS genetics · 2013Article
- Mutations in non-acid patch residues disrupt H2A.Z's association with chromatin through multiple mechanisms.PloS one · 2013Article
- Regulation of histone gene expression in budding yeast.Genetics · 2012Review
- A common telomeric gene silencing assay is affected by nucleotide metabolism.Molecular cell · 2011Article
- Article
- SWI/SNF and Asf1 independently promote derepression of the DNA damage response genes under conditions of replication stress.PloS one · 2011Article
- Individual lysine acetylations on the N terminus of Saccharomyces cerevisiae H2A.Z are highly but not differentially regulated.The Journal of biological chemistry · 2010Article
- Elevated histone expression promotes life span extension.Molecular cell · 2010Article
- Roles for Gcn5 in promoting nucleosome assembly and maintaining genome integrity.Cell cycle (Georgetown, Tex.) · 2010Article
- Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae.Molecular and cellular biology · 2009Article
- Gene-specific transcriptional activation mediated by the p150 subunit of the chromatin assembly factor 1.The Journal of biological chemistry · 2009Article
- Evidence for gene-specific rather than transcription rate-dependent histone H3 exchange in yeast coding regions.PLoS computational biology · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
We investigated the function of the histone H3/H4 chaperones anti-silencing function 1 (Asf1p) and chromatin assembly factor 1 (CAF-1) in global transcriptional regulation in budding yeast. Deletion of ASF1 or CAF-1 components led to global transcriptional misregulation, both activation and repression, of genes scattered throughout the 16 yeast chromosomes. To investigate direct effects on gene regulation, we developed an approach to destabilize Asf1p that results in its rapid degradation within minutes of transcriptional repression. Upon degradation of Asf1p, rapid global changes in gene expression occur without the requirement for passage through S phase or de novo protein synthesis. In particular, we demonstrate that the previously reported influence of Asf1p on histone gene expression is not a direct effect of loss of Asf1p. These data indicate that the histone chaperones CAF-1 and Asf1p regulate the gene expression of a broad array of genes in yeast and, in the case of Asf1p, this is likely to be due to a direct role in chromatin modulation during transcriptional regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.