ArticleMolecular and cellular biology2005
Lymphotropic Herpesvirus saimiri uses the SMN complex to assemble Sm cores on its small RNAs.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Shaping the host cell environment with viral noncoding RNAs.Seminars in cell & developmental biology · 2023Review
- Allosteric regulation of noncoding RNA function by microRNAs.Nucleic acids research · 2022Article
- The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation.Nucleic acids research · 2018Article
- A viral Sm-class RNA base-pairs with mRNAs and recruits microRNAs to inhibit apoptosis.Nature · 2017Article
- Host miRNA degradation by Herpesvirus saimiri small nuclear RNA requires an unstructured interacting region.RNA (New York, N.Y.) · 2016Article
- Viral noncoding RNAs: more surprises.Genes & development · 2015Review
- SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease.Seminars in cell & developmental biology · 2014Review
- Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.Nucleic acids research · 2013Article
- Gemin5 promotes IRES interaction and translation control through its C-terminal region.Nucleic acids research · 2013Article
- Common pathways of autoimmune inflammatory myopathies and genetic neuromuscular disorders.Clinical reviews in allergy & immunology · 2012Review
- A primate herpesvirus uses the integrator complex to generate viral microRNAs.Molecular cell · 2011Article
- Autoantibodies to survival of motor neuron complex in patients with polymyositis: immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins.Arthritis and rheumatism · 2011Article
- Article
- Down-regulation of a host microRNA by a viral noncoding RNA.Cold Spring Harbor symposia on quantitative biology · 2010Review
- Evolutionary diversification of the Sm family of RNA-associated proteins.Molecular biology and evolution · 2008Review
- Chaperoning ribonucleoprotein biogenesis in health and disease.EMBO reports · 2007Review
- Identification of a novel human immunodeficiency virus type 1 integrase interactor, Gemin2, that facilitates efficient viral cDNA synthesis in vivo.Journal of virology · 2006Article
- Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs.Molecular and cellular biology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lymphotropic Herpesvirus saimiri (HVS) causes acute leukemia, T-cell lymphoma, and death in New World monkeys. HVS encodes seven small RNAs (HSURs) of unknown function. The HSURs acquire host Sm proteins and assemble Sm cores similar to those found on the spliceosomal small nuclear RNPs (snRNPs). Here we show that, like host snRNPs, HSURs use the SMN (survival of motor neurons) complex to assemble Sm cores. The HSURs bind the SMN complex directly and with very high affinity, similar to or higher than that of host snRNAs, and can outcompete host snRNAs for SMN-dependent assembly into RNPs. These observations highlight the general utility of the SMN complex for RNP assembly and suggest that infectious agents that engage the SMN complex may burden SMN-dependent pathways, possibly leading to a deleterious reduction in available SMN complex for essential host functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.