ArticleThe American journal of pathology2005
Expression of the T-cell transcription factors, GATA-3 and T-bet, in the neoplastic cells of Hodgkin lymphomas.
Article in The American journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma.Nature communications · 2013Pooled it
- Is GATA3 Useful for Differentiating between Classical Hodgkin Lymphoma and Nodular Lymphocyte-Predominant Hodgkin lymphoma? A Two-Center Study in Tehran, Iran during 2016 to 2022.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- GATA3 Immunohistochemical Staining in Classical Hodgkin Lymphoma and Its Diagnostic Utility in Differential DiagnosisTurkish journal of haematology : official journal of Turkish Society of Haematology · 2025Article
- Expression Patterns of GATA3 in Classical Hodgkin Lymphoma: A Clinico-Pathological Study.Diseases (Basel, Switzerland) · 2024Article
- Article
- Primary Diffuse Large B-Cell Lymphoma of the Urinary Bladder: Update on a Rare Disease and Potential Diagnostic Pitfalls.Current oncology (Toronto, Ont.) · 2022Review
- The Grey Zones of Classic Hodgkin Lymphoma.Cancers · 2022Review
- Establishment of the TBX-code reveals aberrantly activated T-box gene TBX3 in Hodgkin lymphoma.PloS one · 2021Article
- Structural and conformational changes induced by missense variants in the zinc finger domains of GATA3 involved in breast cancer.RSC advances · 2020Article
- Systematic Analysis of Competing Endogenous RNA Networks in Diffuse Large B-Cell Lymphoma and Hodgkin's Lymphoma.Frontiers in genetics · 2020Article
- The c-Jun and JunB transcription factors facilitate the transit of classical Hodgkin lymphoma tumour cells through GScientific reports · 2018Article
- Aberrant expression of NKL homeobox gene HLX in Hodgkin lymphoma.Oncotarget · 2018Article
- Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis.Oncotarget · 2016Article
- Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs.The Journal of clinical investigation · 2016Article
- Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma.Oncotarget · 2015Article
- Aberrantly Expressed OTX Homeobox Genes Deregulate B-Cell Differentiation in Hodgkin Lymphoma.PloS one · 2015Article
- PAX5 overexpression is not enough to reestablish the mature B-cell phenotype in classical Hodgkin lymphoma.Leukemia · 2014Article
- GATA3 mutations found in breast cancers may be associated with aberrant nuclear localization, reduced transactivation and cell invasiveness.Hormones & cancer · 2013Article
- Article
- A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).Nature genetics · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin lymphoma (HL) generally have immunoglobulin gene rearrangements, they are considered to be of B-cell origin. One of the characteristics of HRS cells is a prominent production of various cytokines and chemokines. Cytokine production is generally driven by expression of T-cell transcription factors (TFs). Only limited information is available on the expression of T-cell TFs in HL. Expression of four T-cell TFs and the target cytokine spectrum of these TFs were analyzed in six HL and three large B-cell lymphoma (LBCL) cell lines using quantitative PCR. ERM expression was observed in all HL and LBCL cell lines. Out of HL cell lines, T-bet was expressed in five, GATA-3 in four, and c-Maf in two cell lines. Immunohistochemistry in HL tissues revealed that in 11 of 12 (92%) of the classical HL cases HRS cells were GATA-3 and/or T-bet positive. In three of six cases of nodular lymphocyte predominance type of HL, the neoplastic cells were T-bet positive. Overall, the T-cell TF and cytokine profiles of the HL cell lines showed a considerable degree of consistency. The expression of T-cell TFs may explain the production of various cytokines by HL cell lines and HRS cells.
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