ArticleThe Journal of cell biology2005
Centrosome fragments and microtubules are transported asymmetrically away from division plane in anaphase.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Inactivation of microtubule organizing center function of the centrosome is required for neuronal development and centriole elimination.bioRxiv : the preprint server for biology · 2025Article
- Lateral and longitudinal compaction of PRC1 overlap zones drives stabilization of interzonal microtubules.Molecular biology of the cell · 2023Article
- Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis.Nature communications · 2022Article
- Article
- Centrosome instability: when good centrosomes go bad.Cellular and molecular life sciences : CMLS · 2021Review
- A two-step mechanism for the inactivation of microtubule organizing center function at the centrosome.eLife · 2019Article
- Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation.Molecular biology of the cell · 2017Article
- Centrosome centering and decentering by microtubule network rearrangement.Molecular biology of the cell · 2016Article
- Using Fluorescence Microscopy to Study Mitosis.Methods in molecular biology (Clifton, N.J.) · 2016Article
- A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes.Nature communications · 2015Article
- A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation.eLife · 2015Article
- Lateral motion and bending of microtubules studied with a new single-filament tracking routine in living cells.Biophysical journal · 2014Article
- Nonmuscle myosin II isoforms coassemble in living cells.Current biology : CB · 2014Article
- Eg5 restricts anaphase B spindle elongation in mammalian cells.Cytoskeleton (Hoboken, N.J.) · 2014Article
- Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events.Cell cycle (Georgetown, Tex.) · 2014Article
- MAP65/Ase1 promote microtubule flexibility.Molecular biology of the cell · 2013Article
- Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells.Cytoskeleton (Hoboken, N.J.) · 2012Review
- Cell cycle-regulated cortical dynein/dynactin promotes symmetric cell division by differential pole motion in anaphase.Molecular biology of the cell · 2012Article
- Dynamic reorganization of Eg5 in the mammalian spindle throughout mitosis requires dynein and TPX2.Molecular biology of the cell · 2012Article
- Mitotic centromere-associated kinesin (MCAK) mediates paclitaxel resistance.The Journal of biological chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinning disc confocal microscopy of LLCPK1 cells expressing GFP-tubulin was used to demonstrate that microtubules (MTs) rapidly elongate to the cell cortex after anaphase onset. Concurrently, individual MTs are released from the centrosome and the centrosome fragments into clusters of MTs. Using cells expressing photoactivatable GFP-tubulin to mark centrosomal MT minus ends, a sevenfold increase in MT release in anaphase is documented as compared with metaphase. Transport of both individually released MTs and clusters of MTs is directionally biased: motion is directed away from the equatorial region. Clusters of MTs retain centrosomal components at their focus and the capacity to nucleate MTs. Injection of mRNA encoding nondegradable cyclin B blocked centrosome fragmentation and the stimulation of MT release in anaphase despite allowing anaphase-like chromosome segregation. Biased MT release may provide a mechanism for MT-dependent positioning of components necessary for specifying the site of contractile ring formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.