ArticleClinical and experimental immunology1992
Localization of tumour necrosis factor production in cells at the materno/fetal interface in human pregnancy.
Article in Clinical and experimental immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 119 citations in OpenAlex.
- An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance.American journal of obstetrics and gynecology · 2015Review
- The possible role of extravillous trophoblast-derived exosomes on the uterine spiral arterial remodeling under both normal and pathological conditions.BioMed research international · 2014Review
- LPS-challenged TNFα production, prostaglandin secretion, and TNFα/TNFRs expression in the endometrium of domestic cats in estrus or diestrus, and in cats with pyometra or receiving medroxyprogesterone acetate.Mediators of inflammation · 2014Article
- Article
- Expression pattern of tumor necrosis factor alpha in placentae of idiopathic fetal growth restriction.Journal of molecular histology · 2012Article
- The expression of thioredoxin-1 in preterm delivery placenta.Redox report : communications in free radical research · 2012Article
- Interleukin 10 and tumor necrosis factor-alpha in pregnancy: aspects of interest in clinical obstetrics.ISRN obstetrics and gynecology · 2012Article
- Human cytomegalovirus-induces cytokine changes in the placenta with implications for adverse pregnancy outcomes.PloS one · 2012Article
- Mechanisms of leukocyte accumulation and activation in chorioamnionitis: interleukin 1 beta and tumor necrosis factor alpha enhance colony stimulating factor 2 expression in term decidua.Reproductive sciences (Thousand Oaks, Calif.) · 2009Article
- Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium.Placenta · 2009Review
- Role of tumor necrosis factor-α in Gram-negative bacterial lipopolysaccharides induced implantation failure.Reproductive medicine and biology · 2005Article
- Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia.The American journal of pathology · 2004Article
- Article
- Decidual T lymphocyte activation in hydatidiform mole.Journal of clinical pathology · 1999Article
- Soluble mediators and cytokines produced by human CD3- leucocyte clones from decidualized endometrium.Immunology · 1996Article
- Circulating cytokine concentrations and cytokine production by monocytes from newborn babies and adults.Pflugers Archiv : European journal of physiology · 1994Article
- Analysis of p60 and p80 tumor necrosis factor-alpha receptor messenger RNA and protein in human placentas.The American journal of pathology · 1993Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biologically active tumour necrosis factor (TNF) was detected in medium conditioned by incubation with explants of human pregnancy decidua or fetal chorionic villous tissue, taken in the first trimester and at term. Addition of endotoxin increased TNF release in most cases. ELISA assays gave similar results for TNF-alpha and also demonstrated low levels of TNF-beta. Using cell populations purified by flow cytometry, secretion of biologically active TNF was shown to be localized to the macrophages. Cytotrophoblast purified from term amniochorion produced no TNF. Both decidual and chorionic villous tissue at term contained mRNA for TNF-alpha and TNF-beta. TNF-alpha mRNA was confined to decidual macrophages in first trimester tissue, and was not present in chorionic cytotrophoblast. TNF-beta mRNA, in contrast, was detected in both macrophage and non-macrophage populations in term decidua.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.