ArticleClinical and experimental immunology1992
Modulation of the cellular immune response during Plasmodium falciparum infections in sickle cell trait individuals.
Article in Clinical and experimental immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Trial
- Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia.The Journal of infectious diseases · 2015Article
- Biochemical and immunological mechanisms by which sickle cell trait protects against malaria.Malaria journal · 2013Review
- World distribution, population genetics, and health burden of the hemoglobinopathies.Cold Spring Harbor perspectives in medicine · 2012Review
- Sickle cell trait, hemoglobin C trait, and invasive pneumococcal disease.Epidemiology (Cambridge, Mass.) · 2010Article
- Frequencies of peripheral blood myeloid cells in healthy Kenyan children with alpha+ thalassemia and the sickle cell trait.The American journal of tropical medicine and hygiene · 2006Article
- Increased plasma levels of soluble IL-2R are associated with severe Plasmodium falciparum malaria.Clinical and experimental immunology · 1994Article
- Biological significance of soluble IL-2 receptor.Mediators of inflammation · 1993Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Plasma and peripheral blood mononuclear cells (PBMC) were obtained from P. falciparum-infected individuals with and without the sickle cell trait at diagnosis and 7 days after treatment. HbAA and HbAS patients were compared for levels of plasma soluble IL-2 receptors (IL-2R) and the in vitro cellular reactivity to affinity-purified soluble P. falciparum antigens (SPAg), PPD and phytohaemagglutinin (PHA). At diagnosis, HbAS patients with clinical disease had lower plasma-soluble IL-2R levels and parasite counts than the corresponding HbAA patients, whereas HbAS and HbAA patients with asymptomatic infections had comparable soluble IL-2R levels and parasite counts. PBMC from HbAS patients had higher proliferation and IFN-gamma production in response to SPAg than PBMC from HbAA patients. The difference in the lymphoproliferative responses to SPAg between the two groups was evident in patients with asymptomatic infections. In all patients, the clinical severity, the soluble IL-2R levels and the parasite counts were directly related. The former two were inversely related to the proliferative responses to SPAg. After treatment, all the studied parameters were comparable in the two groups. The study indicates that during P. falciparum infection, HbAS compared with HbAA patients had lower in vivo cellular activation and higher in vitro cellular reactivity in response to soluble malaria antigens.
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Registered trials
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