ArticleJournal of molecular medicine (Berlin, Germany)2005
A single-nucleotide polymorphism in human angiotensinogen gene is associated with essential hypertension and affects glucocorticoid induced promoter activity.
Article in Journal of molecular medicine (Berlin, Germany), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Association Between Interleukin-6 -572 C>G and -174 G>C Polymorphisms and Hypertension: A Meta-analysis of Case-control Studies.Medicine · 2016Pooled it
- Association of IL-6 polymorphisms with hepatocellular carcinoma risk: evidences from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Lacidipine Ameliorates the Endothelial Senescence and Inflammatory Injury Through CXCR7/P38/C/EBP-β Signaling Pathway.Frontiers in cardiovascular medicine · 2021Article
- Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics.Scientific reports · 2017Article
- Article
- Association of angiotensinogen gene SNPs and haplotypes with risk of hypertension in eastern Indian population.Clinical hypertension · 2017Article
- Dynamic regulation of the angiotensinogen gene by DNA methylation, which is influenced by various stimuli experienced in daily life.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Review
- Dexamethasone promotes hypertension by allele-specific regulation of the human angiotensinogen gene.The Journal of biological chemistry · 2015Article
- Transgenic mice with -6A haplotype of the human angiotensinogen gene have increased blood pressure compared with -6G haplotype.The Journal of biological chemistry · 2010Article
- Angiotensinogen promoter variants influence gene expression in human kidney and visceral adipose tissue.Journal of human hypertension · 2010Article
- The renin angiotensin system and the metabolic syndrome.The open hypertension journal · 2010Article
- Urinary angiotensinogen accurately reflects intrarenal Renin-Angiotensin system activity.American journal of nephrology · 2010Article
- A growing chain of evidence linking genetic variation in angiotensinogen with essential hypertension: focus on "a haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G," by Jain et al.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- A haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Upstream stimulatory factor is required for human angiotensinogen expression and differential regulation by the A-20C polymorphism.Circulation research · 2008Article
- N-acetyltransferase 8, a positional candidate for blood pressure and renal regulation: resequencing, association and in silico study.BMC medical genetics · 2008Article
- Differential susceptibility to hypertension is due to selection during the out-of-Africa expansion.PLoS genetics · 2005Article
- Oscar M. Helmer, you had it right.Journal of molecular medicine (Berlin, Germany) · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Hypertension is a serious health problem particularly for African-Americans. Previous studies have suggested that angiotensinogen (AGT) gene locus is involved in human essential hypertension. We have recently shown that an A/G polymorphism at -217 in the promoter of the AGT gene is associated with essential hypertension especially in African-Americans. We report here that A/G polymorphism at -217 affects the glucocorticoid-induced promoter activity of the human AGT gene. We show that recombinant glucocorticoid receptor (GR) binds strongly to the AGT gene promoter when nucleoside A is present at -217, and dexamethasone treatment increases the interleukin 6 induced promoter activity of reporter constructs containing nucleoside A at -217. Similarly cotransfection of GR and C/EBP beta or C/EBP delta increases the promoter activity of reporter construct containing nucleoside A at -217. Since AGT is an acute phase protein, we propose that increased expression of -217A allele of the AGT gene by glucocorticoids and C/EBP family of transcription factors may be involved in essential hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.